Xentry
Xentry is a cell-penetrating peptide (CCP) consisting of only 7 amino acids of hepatitis B virus: LCLRPVG. Xentry-linked anti-B-raf antibodies and siRNAs demonstrates the capability to kill B-raf-dependent melanoma cells. Xentry alone or conjugated to β-galactosidase leads to its delivery to most tissues in mice, except circulating blood cells. Xentry can be used for the delivery of large molecules (antibodies, siRNA, enzymes) .
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- No. CAS: 1352335-71-7
- Fòrmula: C33H60N10O8S
- Peso molecular:756.96
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
In Vitro
Xentry (10 μM) penetrates adherent cells energy-dependently, including HepG2 (liver), C32 (melanoma), DU145 (prostate), H441 (lung), BT474 (breast), Cos (kidney), and Rin-m5F (pancreatic b-cell) cell lines, but not nonadherent resting blood cells[1].
Xentry (10-20 μM, 4 h) conjugated to β-galactosidase is internalized by living HepG2 cells, and enters cells via a syndecan pathway[1].
Xentry (1 h) effectively delivers antibodies and siRNA to melanoma cells, inducing apoptosis of B-raf-dependent melanoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
TAMRA-labelled Xentry (2-100 μg/mL, i.v., single dose) successfully delivers the macromolecular complex to multiple tissues in Balb/c mice, specifically enriching in small intestinal epithelial cells and marginal sinus of the spleen[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1352335-71-7
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Peso molecular 756.96
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Fòrmula C33H60N10O8S
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Sequence
Leu-Cys-Leu-Arg-Pro-Val-Gly
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Sequence Shortening
LCLRPVG
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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RNA interference technology
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing gene transcription or activating RNA degradation. This mechanism was discovered in plants in 1998 by Andrew Fire and Craig Mello. Today, this phenomenon can be observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Xentry Related Classifications
HY-P11083 Related Classifications
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