Tigit - T cell immunoreceptor with Ig and ITIM domains Gene

Also Known as Vstm3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 100043314

Summary

Enables signaling receptor binding activity. Acts upstream of or within negative regulation of T cell activation. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and ITIM domains). [provided by Alliance of Genome Resources, Apr 2022]

Tigit Products (1)

mRNA Protein Name
NM_001146325.1 NP_001139797.1 T-cell immunoreceptor with Ig and ITIM domains precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24658051 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
21416464 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of T cell activation IMP
IMP: Inferred from mutant phenotype
21199897 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-cell immunoreceptor with Ig and ITIM domains

  • V-set and transmembrane domain containing 3

  • V-set and transmembrane domain-containing protein 3

Recombinant Tigit Proteins

Cat. No. Product Name Accession Purity
HY-P71009 TIGIT Protein, Mouse (118a.a, HEK293, Fc) NP_001139797 (G26-T143) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72449 TIGIT Protein, Mouse (110a.a, HEK293, His) NP_001139797 (G26-F135) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77235 TIGIT Protein, Mouse (HEK293, mFc) NP_001139797 (A17-G141) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0070A Liothyronine Activator 99.82% Unkown

Clinical Phase

Inhibitory Antibodies (17)
Cat. No. Product Name Effect
Purity Phase
HY-P9986 Tiragolumab Inhibitor 99.04% Phase 3
HY-P99858 Domvanalimab Inhibitor 98.62% Phase 3
HY-P990032 Belrestotug Inhibitor 97% Phase 3
HY-P990704 Rilvegostomig Inhibitor 99.00% Phase 3
HY-P99202 Vibostolimab Inhibitor 96.54% Phase 2
HY-P990960 Lucorafusp alfa 98.14% Phase 2
HY-P990079 Renvistobart Inhibitor 99.95% Phase 2
HY-P990746 Lancastotug Inhibitor 95.432% Phase 2
HY-P990031 Dargistotug 99.36% Phase 2
HY-P991394 SEA-TGT Inhibitor / Phase 2
HY-P990030 Ralzapastotug Inhibitor 98.67% Phase 1
HY-P991389 BAT-6005 Inhibitor 95.89% Phase 1
HY-P991386 PM-1021 Inhibitor / Phase 1
HY-P991390 BAT-6021 Inhibitor / Phase 1
HY-P991393 ASP8374 / Phase 1
HY-P991620 JS006 Inhibitor / Phase 1
HY-P991391 COM902 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-185098 PD1-PDL1-IN-4 Inhibitor / Unkown
HY-A0070AS5 Liothyronine-d4 / Unkown
HY-RS14524 TIGIT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16565 Tigit Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22998 Tigit Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990155 Anti-Mouse TIGIT Antibody (1G9) Inhibitor 99.71% Unkown
HY-P992121 Nilvanstomig Inhibitor / Unkown
HY-P991387 AGEN1307 Inhibitor / Unkown
HY-P991475 MG-1131 / Unkown
HY-P992361 HB0030 / Unkown
HY-P991111 Anti-Mouse TIGIT Antibody (10A7) Inhibitor 98.37% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tigit NCBI NCBI:201633