Relb - RELB proto-oncogene, NF-kB subunit Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 100360982

About Relb

Primary_assembly 1: 79,257,725-79,285,507 reverse strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 195 orthologues, 4 paralogues and is associated with 13 phenotypes. Biased expression in Spleen (RPKM 67.), Thymus (RPKM 49.5) and 9 other tissues.

Summary

Enables DNA binding activity. Involved in cellular response to osmotic stress. Located in nucleus. Used to study kidney disease; muscular atrophy; and ureteral obstruction. Biomarker of prediabetes syndrome. Human ortholog(s) of this gene implicated in breast Cancer and immunodeficiency 53. Orthologous to human RelB (RelB proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]

Relb Products (6)

mRNA Protein Name
XM_006228503.4 XP_006228565.1 transcription factor RelB isoform X2
XM_017590004.2 XP_017445493.1 transcription factor RelB isoform X4
XM_008759054.3 XP_008757276.1 transcription factor RelB isoform X5
XM_017590005.2 XP_017445494.1 transcription factor RelB isoform X4
XM_017590003.2 XP_017445492.1 transcription factor RelB isoform X3
XM_006228502.4 XP_006228564.1 transcription factor RelB isoform X1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
17250675 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to osmotic stress IDA
IDA: Inferred from direct assay
16716309 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Relb Protein Structure

RelB_leu_zip

RelB_leu_zip: pfam16180 (0 - 76)

RHD-n_RelB

RHD-n_RelB: cd07886 (103 - 274)

RHD_dimer

RHD_dimer: pfam16179 (282 - 378)

RelB_transactiv

RelB_transactiv: cl24684 (381 - 558)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 559 a.a.
Protein Preferred Names Protein Names

transcription factor RelB

  • avian reticuloendotheliosis viral (v-rel) oncogene related B

  • v-rel avian reticuloendotheliosis viral oncogene homolog B

  • v-rel reticuloendotheliosis viral oncogene homolog B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-14645 (-)-DHMEQ Inhibitor 99.81% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Relb NCBI NCBI:5971