PTPRU - protein tyrosine phosphatase receptor type U Gene

Also Known as FMI; PTP; PCP-2; PTP-J; PTPRO; PTPU2; PTP-PI; PTP-RO; PTPPSI; hPTP-J; R-PTP-U; R-PTP-PSI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10076

About PTPRU

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:29,236,522-29,326,800 (from NCBI)

This gene has 11 transcripts (splice variants), 279 orthologues and 35 paralogues. Broad expression in placenta (RPKM 9.6), lung (RPKM 7.2) and 21 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]

PTPRU Products (4)

mRNA Protein Name
NM_001195001.2 NP_001181930.1 receptor-type tyrosine-protein phosphatase U isoform 4 precursor
NM_005704.5 NP_005695.3 receptor-type tyrosine-protein phosphatase U isoform 3 precursor
NM_133177.4 NP_573438.3 receptor-type tyrosine-protein phosphatase U isoform 2 precursor
NM_133178.4 NP_573439.2 receptor-type tyrosine-protein phosphatase U isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
16574648 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10397721 GOA
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
12501215 GOA
enables protein tyrosine phosphatase activity IMP
IMP: Inferred from mutant phenotype
16574648 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
16574648 GOA
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
12501215 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
16574648 GOA
involved in positive regulation of cell-cell adhesion mediated by cadherin IDA
IDA: Inferred from direct assay
16574648 GOA
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
12501215 GOA
involved in protein localization to cell surface IDA
IDA: Inferred from direct assay
16574648 GOA
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
12501215 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRU Protein Structure

MAM

MAM: MAM domain, meprin/A5/mu (27 - 187)

fn3

fn3: Fibronectin type III domain (292 - 367)

fn3

fn3: Fibronectin type III domain (496 - 577)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (917 - 1143)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (1203 - 1438)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1446 a.a.
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase U

  • PTP pi

PTPRU Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PTPRU Q92729 KIT Homo sapiens P10721
Anti Bait CoIP
10397721
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Plague

  • Yersiniosis

  • Yersinia Infections

  • Infection By Yersinia Pestis

  • Pasteurella Pestis Infection

  • Pestilential Fever

  • Yersinia Pestis Infection
Focal Segmental Glomerulosclerosis

  • Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

  • Focal Glomerulosclerosis

  • Fsgs

  • Segmental Glomerulosclerosis

  • Glomerulosclerosis, Focal Segmental

  • Fgs

  • Focal Glomerular Sclerosis

  • Familial Idiopathic Nephrotic Syndrome

  • Focal Sclerosis With Hyalinosis

  • Glomerulosclerosis, Focal

  • Glomerulosclerosis Focal

  • Glomerulosclerosis, Segmental, Focal

  • Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Myasthenic Syndrome, Congenital, 6, Presynaptic

  • Familial Infantile Myasthenia

  • CMS6

  • Cmsea

  • Congenital Myasthenic Syndrome 6

  • Familial Infantile Myasthenia Gravis 2

  • Fimg2

  • Myasthenic Syndrome, Congenital, Associated With Episodic Apnea

  • Myasthenic Syndrome, Presynaptic, Congenital, Associated With Episodic Apnea

  • Congenital Myasthenic Syndrome Type Ia2, Formerly

  • Cms1a2, Formerly

  • Cms Ia2, Formerly

  • Myasthenia, Familial Infantile, Formerly

  • Fim, Formerly

  • Myasthenia Gravis, Familial Infantile, 2, Formerly

  • Fimg2, Formerly

  • Cms Ia2

  • Cms1a2

  • Congenital Myasthenic Syndrome 6, Presynaptic

  • Congenital Myasthenic Syndrome Type Ia2

  • Congenital Presynaptic Myasthenic Syndrome Associated With Episodic Apnea

  • Fim

  • Cms1a

  • Cms-Ea

  • Cms Ia

  • Congenital Myasthenic Syndrome Pre-Synaptic Associated With Episodic Apnea

  • Congenital Myasthenic Syndrome Type 1a

  • Congenital Myasthenic Syndrome Type Ia

  • Myasthenic Syndrome, Congenital, Type 6, Presynaptic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11451 PTPRU Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PTPRU VGNC VGNC:45200
Macaca mulatta PTPRU VGNC VGNC:76624
Bos taurus PTPRU VGNC VGNC:33559
Mus musculus PTPRU MGD MGI:1321151
Rattus norvegicus PTPRU RGD RGD:620782
Felis catus PTPRU VGNC VGNC:69183
Others PTPRU NCBI