2. Gene
  3. ADGRG2 - adhesion G protein-coupled receptor G2 Gene

ADGRG2 - adhesion G protein-coupled receptor G2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HE6; EDDM6; GPR64; CBAVDX; TM7LN2

Gene ID: 10149 | Gene type: protein coding

About ADGRG2

Cytogenetic location: Xp22.13 Genomic coordinates (GRCh38): X:18,989,307-19,122,956 (from NCBI)

This gene has 11 transcripts (splice variants), 219 orthologues, 42 paralogues and is associated with 2 phenotypes. Biased expression in stomach (RPKM 3.6), lymph node (RPKM 2.3) and 13 other tissues.

Summary

This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

ADGRG2 Products(9)

mRNA Protein Name
NM_001079858.3 NP_001073327.1 adhesion G-protein coupled receptor G2 isoform 1 precursor
NM_001079859.3 NP_001073328.1 adhesion G-protein coupled receptor G2 isoform 2 precursor
NM_001079860.3 NP_001073329.1 adhesion G-protein coupled receptor G2 isoform 3 precursor
NM_001184833.2 NP_001171762.1 adhesion G-protein coupled receptor G2 isoform 5 precursor
NM_001184834.2 NP_001171763.1 adhesion G-protein coupled receptor G2 isoform 6 precursor
NM_001184835.2 NP_001171764.1 adhesion G-protein coupled receptor G2 isoform 7 precursor
NM_001184836.2 NP_001171765.1 adhesion G-protein coupled receptor G2 isoform 8 precursor
NM_001184837.2 NP_001171766.1 adhesion G-protein coupled receptor G2 isoform 9 precursor
NM_005756.4 NP_005747.2 adhesion G-protein coupled receptor G2 isoform 4 precursor

ADGRG2 Protein Structure

GPS

GPS: GPCR proteolysis site, GPS, motif (568 - 612)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (626 - 875)

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  • 1017 a.a.
Protein Preferred Names Protein Names

adhesion G-protein coupled receptor G2

G protein-coupled receptor 64

Related Diseases

Diseases Alias
Vas Deferens, Congenital Bilateral Aplasia Of, X-Linked

CBAVDX

Congenital Bilateral Absence Of Vas Deferens, X-Linked

X-Linked Congenital Bilateral Absence Of Vas Deferens

Congenital Bilateral Aplasia Of The Vas Deferens, X-Linked

Male Urogenital Diseases
Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens

CBAVD

Cavd

Congenital Bilateral Aplasia Of Vas Deferens

Congenital Bilateral Absence Of The Vas Deferens

Congenital Bilateral Agenesis Of Vas Deferens

Absence Of Vas Deferens

Absent Vasa

Congenital Absence Of Vas Deferens

Congenital Aplasia Of Vas Deferens

Absent Vas Deferens

Vas Deferens, Congenital Bilateral Absence
Infertility
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00355 ADGRG2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ADGRG2 VGNC VGNC:37644
Rattus norvegicus ADGRG2 RGD RGD:628618
Bos taurus ADGRG2 VGNC VGNC:25666
Macaca mulatta ADGRG2 VGNC VGNC:69802
Mus musculus ADGRG2 MGD MGI:2446854
Felis catus ADGRG2 VGNC VGNC:67436