PRDX4 - peroxiredoxin 4 Gene

Also Known as PRX-4; AOE372; AOE37-2; HEL-S-97n

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10549

About PRDX4

Cytogenetic location: Xp22.11 Genomic coordinates (GRCh38): X:23,667,493-23,686,397 (from NCBI)

This gene has 5 transcripts (splice variants), 212 orthologues and 4 paralogues. Ubiquitous expression in pancreas (RPKM 49.0), liver (RPKM 22.7) and 25 other tissues.

Summary

The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]

PRDX4 Products (1)

mRNA Protein Name
NM_006406.2 NP_006397.1 peroxiredoxin-4 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
21916849 GOA
enables molecular sequestering activity IDA
IDA: Inferred from direct assay
21916849 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17644091 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDX4 Protein Structure

AhpC-TSA

AhpC-TSA: AhpC/TSA family (82 - 213)

1-cysPrx_C

1-cysPrx_C: C-terminal domain of 1-Cys peroxiredoxin (234 - 264)

  • 0
  • 100
  • 200
  • 271 a.a.
Protein Preferred Names Protein Names

peroxiredoxin-4

  • antioxidant enzyme AOE372

PRDX4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRDX4 Q13162 TXNDC5 Homo sapiens Q8NBS9
Enzymatic Study
21057456
Intra
PRDX4 Q13162 TBXA2R Homo sapiens P21731
Pull Down
17644091
Intra
PRDX4 Q13162 TBXA2R Homo sapiens P21731
Anti Tag CoIP
17644091
Intra
PRDX4 Q13162 TBXA2R Homo sapiens P21731
Y2H
17644091
Intra
PRDX4 Q13162 PRDX1 Homo sapiens Q06830
Anti Tag CoIP
33961781
Intra
PRDX4 Q13162 LBP Homo sapiens P18428
Anti Tag CoIP
21988832
Intra
PRDX4 Q13162 LBP Homo sapiens P18428
Pull Down
21988832
Intra
PRDX4 Q13162 P4HB Homo sapiens P07237
Enzymatic Study
21057456
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRDX4 Proteins

Cat. No. Product Name Accession Purity
HY-P71232 PRDX4 Protein, Human (His) Q13162 (W38-N271) ≥ 95%, as determined by reducing SDS-PAGE.

PRDX4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81698 Peroxiredoxin 4 Antibody (YA1443) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Hypoascorbemia

  • Scurvy

  • Ascorbic Acid Deficiency

  • Vitamin C Deficiency

  • Vitamin C, Inability To Synthesize

  • Deficiency Of Vitamin C

  • Scorbutus

  • Vitamin C
Filariasis

  • Disease Due To Superfamily Filarioidea

  • Bancroftian Filarial Fever

  • Mumu

  • Wanganga

  • Bancroftian Filariasis

  • Wuchereriosis

  • Brugiosis

  • Malayan Filariasis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18834 Prdx4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11077 PRDX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25326 Prdx4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PRDX4 VGNC VGNC:64347
Macaca mulatta PRDX4 VGNC VGNC:76272
Bos taurus PRDX4 VGNC VGNC:33302
Rattus norvegicus PRDX4 RGD RGD:620043
Canis familiaris PRDX4 VGNC VGNC:44952
Mus musculus PRDX4 MGD MGI:1859815
Others PRDX4 NCBI