USP16 - ubiquitin specific peptidase 16 Gene

Also Known as UBPM; UBP-M

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10600

About USP16

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:29,024,668-29,054,488 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 71 paralogues. Ubiquitous expression in thyroid (RPKM 20.1), testis (RPKM 16.3) and 25 other tissues.

Summary

This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of Mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

USP16 Products (3)

mRNA	Protein	Name
NM_001001992.2	NP_001001992.1	ubiquitin carboxyl-terminal hydrolase 16 isoform b
NM_001032410.2	NP_001027582.1	ubiquitin carboxyl-terminal hydrolase 16 isoform a
NM_006447.3	NP_006438.1	ubiquitin carboxyl-terminal hydrolase 16 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	17914355	GOA
enables cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	17914355	GOA
enables histone H2A deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	20550933	GOA
enables histone binding	IDA IDA: Inferred from direct assay	17914355	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA
enables ribosomal small subunit binding	IDA IDA: Inferred from direct assay	32129764	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	17914355	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	17512543	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	17512543	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	20550933	GOA
involved in monoubiquitinated protein deubiquitination	IDA IDA: Inferred from direct assay	32129764	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17914355	GOA
involved in positive regulation of ribosome biogenesis	IDA IDA: Inferred from direct assay	32129764	GOA
involved in positive regulation of translational elongation	IMP IMP: Inferred from mutant phenotype	20550933	GOA
involved in protein homotetramerization	IPI IPI: Inferred from physical interaction	17914355	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	32129764	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17914355	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP16 Protein Structure

zf-UBP

UCH

0
200
400
600
823 a.a.

Protein Preferred Names	Protein Names
ubiquitin carboxyl-terminal hydrolase 16	deubiquitinating enzyme 16

Related Diseases

Diseases	Alias
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15527	USP16 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-172193	UBD1031	Antagonist	/	Unkown
HY-RS15532	USP21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17277	Usp21 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18688	Usp16 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25174	Usp16 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	USP16	VGNC	VGNC:66870
Canis familiaris	USP16	VGNC	VGNC:53051
Rattus norvegicus	USP16	RGD	RGD:1307192
Mus musculus	USP16	MGD	MGI:1921362
Bos taurus	USP16	VGNC	VGNC:52842
Macaca mulatta	USP16	VGNC	VGNC:78738
Others	USP16	NCBI