2. Gene
  3. TRIM16 - tripartite motif containing 16 Gene

TRIM16 - tripartite motif containing 16 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EBBP

Gene ID: 10626 | Gene type: protein coding

About TRIM16

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:15,627,966-15,684,311 (from NCBI)

This gene has 26 transcripts (splice variants), 225 orthologues and 80 paralogues. Broad expression in esophagus (RPKM 47.9), placenta (RPKM 17.3) and 19 other tissues.

Summary

The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory Autophagy. [provided by RefSeq, Jan 2017]

TRIM16 Products(8)

mRNA Protein Name
NM_001348119.1 NP_001335048.1 tripartite motif-containing protein 16 isoform a
NM_001348120.1 NP_001335049.1 tripartite motif-containing protein 16 isoform a
NM_001348121.1 NP_001335050.1 tripartite motif-containing protein 16 isoform b
NM_001348122.1 NP_001335051.1 tripartite motif-containing protein 16 isoform b
NM_001348124.1 NP_001335053.1 tripartite motif-containing protein 16 isoform c
NM_001348125.1 NP_001335054.1 tripartite motif-containing protein 16 isoform c
NM_001348126.1 NP_001335055.1 tripartite motif-containing protein 16 isoform d
NM_006470.4 NP_006461.3 tripartite motif-containing protein 16 isoform a

TRIM16 Protein Structure

zf-B_box

zf-B_box: B-box zinc finger (129 - 165)

PRY

PRY: SPRY-associated domain (375 - 423)

SPRY

SPRY: SPRY domain (427 - 549)

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  • 564 a.a.
Protein Preferred Names Protein Names

tripartite motif-containing protein 16

E3 ubiquitin-protein ligase TRIM16

Related Diseases

Diseases Alias
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

Glomerulonephritis With Sparse Hair And Telangiectases

Telangiectatic Membranoproliferative Glomerulonephritis

HLTRS

Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome

Hlt-Renal Defect Syndrome

Glomerulonephritis Sparse Hair Telangiectases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15024 TRIM16 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TRIM16 RGD RGD:1309749
Bos taurus TRIM16 VGNC VGNC:107280
Mus musculus TRIM16 MGD MGI:2137356
Others TRIM16 NCBI