TRIM16 - tripartite motif containing 16 Gene

Also Known as EBBP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10626

About TRIM16

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:15,627,966-15,684,311 (from NCBI)

This gene has 26 transcripts (splice variants), 225 orthologues and 80 paralogues. Broad expression in esophagus (RPKM 47.9), placenta (RPKM 17.3) and 19 other tissues.

Summary

The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box Zinc Finger Protein family. While it lacks a RING domain found in Other TRIM proteins, the encoded protein can homodimerize or heterodimerize with Other TRIM proteins and has E3 ubiquitin Ligase activity. This gene is also a tumor suppressor and is involved in secretory Autophagy. [provided by RefSeq, Jan 2017]

TRIM16 Products (8)

mRNA	Protein	Name
NM_001348119.1	NP_001335048.1	tripartite motif-containing protein 16 isoform a
NM_001348120.1	NP_001335049.1	tripartite motif-containing protein 16 isoform a
NM_001348121.1	NP_001335050.1	tripartite motif-containing protein 16 isoform b
NM_001348122.1	NP_001335051.1	tripartite motif-containing protein 16 isoform b
NM_001348124.1	NP_001335053.1	tripartite motif-containing protein 16 isoform c
NM_001348125.1	NP_001335054.1	tripartite motif-containing protein 16 isoform c
NM_001348126.1	NP_001335055.1	tripartite motif-containing protein 16 isoform d
NM_006470.4	NP_006461.3	tripartite motif-containing protein 16 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	16636064	GOA
enables NACHT domain binding	IPI IPI: Inferred from physical interaction	16575408	GOA
enables interleukin-1 binding	IPI IPI: Inferred from physical interaction	16575408	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16575408	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16636064	GOA
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	16575408	GOA
involved in positive regulation of keratinocyte differentiation	IDA IDA: Inferred from direct assay	11919186	GOA
involved in positive regulation of retinoic acid receptor signaling pathway	IDA IDA: Inferred from direct assay	16636064	GOA
involved in response to growth hormone	IDA IDA: Inferred from direct assay	11919186	GOA
involved in response to organophosphorus	IEP IEP: Inferred from expression pattern	16079077	GOA
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	16636064	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in PML body	IDA IDA: Inferred from direct assay	16636064	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9817599	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM16 Protein Structure

zf-B_box

PRY

SPRY

0
100
200
300
400
500
564 a.a.

Protein Preferred Names	Protein Names
tripartite motif-containing protein 16	E3 ubiquitin-protein ligase TRIM16

TRIM16 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIM16	O95361	TRIM16L	Homo sapiens	Q309B1	Anti Tag CoIP	33961781
Intra	TRIM16	O95361	TRIM16L	Homo sapiens	Q309B1	Anti Tag CoIP	28514442
Intra	TRIM16	O95361	VIM	Homo sapiens	P08670	Anti Bait CoIP	20729920
Intra	TRIM16	O95361	VIM	Homo sapiens	P08670	Confocal	20729920
Intra	TRIM16	O95361	E2F1	Homo sapiens	Q01094	Anti Tag CoIP	20729920
Intra	TRIM16	O95361	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome	Glomerulonephritis With Sparse Hair And Telangiectases Telangiectatic Membranoproliferative Glomerulonephritis HLTRS Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome Hlt-Renal Defect Syndrome Glomerulonephritis Sparse Hair Telangiectases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15024	TRIM16 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19080	Trim16 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25571	Trim16 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRIM16	RGD	RGD:1309749
Bos taurus	TRIM16	VGNC	VGNC:107280
Mus musculus	TRIM16	MGD	MGI:2137356
Others	TRIM16	NCBI