HCST - hematopoietic cell signal transducer Gene

Also Known as DAP10; KAP10; PIK3AP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10870

About HCST

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,902,529-35,904,377 (from NCBI)

This gene has 2 transcripts (splice variants) and 84 orthologues. Biased expression in bone marrow (RPKM 39.5), spleen (RPKM 20.3) and 12 other tissues.

Summary

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

HCST Products (2)

mRNA	Protein	Name
NM_001007469.2	NP_001007470.1	hematopoietic cell signal transducer isoform 2 precursor
NM_014266.4	NP_055081.1	hematopoietic cell signal transducer isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylinositol 3-kinase binding	IDA IDA: Inferred from direct assay	10426994	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10426994	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	16582911	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	15294961	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	16582911	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	10426994	GOA
involved in protein phosphorylation	IGI IGI: Inferred from genetic interaction	10528161	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	10426994	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	15894612	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HCST Protein Structure

DAP10

0
93 a.a.

Protein Preferred Names	Protein Names
hematopoietic cell signal transducer	DNAX-activation protein 10

HCST Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HCST	Q9UBK5	BDNF	Homo sapiens	P23560-2	Y2H Array	32814053
Intra	HCST	Q9UBK5	BDNF	Homo sapiens	P23560-2	Validated Y2H	32814053
Intra	HCST	Q9UBK5	BDNF	Homo sapiens	P23560-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HCST Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75310	DAP10 Protein, Human (HEK293, mFc)	Q9UBK5 (Q19-P48)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1	Nasu-Hakola Disease Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy Plosl Nhd Presenile Dementia With Bone Cysts Plo-Sl PLOSL1 Dementia, Prefrontal, With Bone Cysts Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease Progressive Dementia With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13195	SLC35A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06057	HCST Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19608	Hcst Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26103	Hcst Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HCST	VGNC	VGNC:73181
Mus musculus	HCST	MGD	MGI:1344360
Canis familiaris	HCST	VGNC	VGNC:53722
Bos taurus	HCST	VGNC	VGNC:29783
Rattus norvegicus	HCST	RGD	RGD:1359238
Others	HCST	NCBI