HCST - hematopoietic cell signal transducer Gene

Homo sapiens

Also known as DAP10; KAP10; PIK3AP

Gene ID: 10870 | Gene type: protein coding

About HCST

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,902,529-35,904,377 (from NCBI)

This gene has 2 transcripts (splice variants) and 84 orthologues. Biased expression in bone marrow (RPKM 39.5), spleen (RPKM 20.3) and 12 other tissues.

Summary

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

HCST Products(2)

mRNA	Protein	Name
NM_001007469.2	NP_001007470.1	hematopoietic cell signal transducer isoform 2 precursor
NM_014266.4	NP_055081.1	hematopoietic cell signal transducer isoform 1 precursor

HCST Protein Structure

DAP10

0
93 a.a.

Protein Preferred Names

Protein Names

hematopoietic cell signal transducer

DNAX-activation protein 10

Recombinant HCST Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75310	DAP10 Protein, Human (HEK293, mFc)	Q9UBK5 (Q19-P48)	≥95%

Related Diseases

Diseases

Alias

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease	Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Plosl	Nhd
Presenile Dementia With Bone Cysts	Plo-Sl
PLOSL1	Dementia, Prefrontal, With Bone Cysts
Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease
Progressive Dementia With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06057	HCST Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HCST	VGNC	VGNC:73181
Mus musculus	HCST	MGD	MGI:1344360
Canis familiaris	HCST	VGNC	VGNC:53722
Bos taurus	HCST	VGNC	VGNC:29783
Rattus norvegicus	HCST	RGD	RGD:1359238
Others	HCST	NCBI