Irak2 - interleukin-1 receptor-associated kinase 2 Gene

Also Known as IRAK-2; 6330415L08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 108960

Summary

Predicted to enable protein heterodimerization activity; protein homodimerization activity; and protein serine/threonine kinase activity. Acts upstream of or within lipopolysaccharide-mediated signaling pathway; negative regulation of DNA-binding transcription factor activity; and positive regulation of NF-kappaB transcription factor activity. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including Peyer's patch; brain; genitourinary system; respiratory system; and thymus. Orthologous to human IRAK2 (interleukin 1 receptor associated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Irak2 Products (2)

mRNA Protein Name
NM_001113553.1 NP_001107025.1 interleukin-1 receptor-associated kinase-like 2 isoform b
NM_172161.4 NP_751893.3 interleukin-1 receptor-associated kinase-like 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11544529 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within lipopolysaccharide-mediated signaling pathway IDA
IDA: Inferred from direct assay
15082713 MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15082713 MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
15082713 MGI
NOT acts upstream of or within positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
12220507 MGI
NOT acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
12220507 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-1 receptor-associated kinase-like 2

  • interleukin-1 receptor-associated kinase 2c

  • mu-IRAK-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70731 IRAK4 aa104-460 Recombinant Human Active Protein Kinase / Unkown
HY-RS06896 IRAK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19016 Irak2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25505 Irak2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irak2 NCBI NCBI:3656