METAP2 - methionyl aminopeptidase 2 Gene

Homo sapiens

Also known as MAP2; MNPEP; p67eIF2

Gene ID: 10988 | Gene type: protein coding

About METAP2

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:95,474,152-95,515,839 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 26.5), lymph node (RPKM 23.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the methionyl Aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of Cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

METAP2 Products(4)

mRNA	Protein	Name
NM_001317182.2	NP_001304111.1	methionine aminopeptidase 2 isoform 2
NM_001317183.2	NP_001304112.1	methionine aminopeptidase 2 isoform 3
NM_001330246.2	NP_001317175.1	methionine aminopeptidase 2 isoform 4
NM_006838.4	NP_006829.1	methionine aminopeptidase 2 isoform 1

METAP2 Protein Structure

Peptidase_M24

0
100
200
300
400
478 a.a.

Protein Preferred Names

Protein Names

methionine aminopeptidase 2

eIF-2-associated p67 homolog

Recombinant METAP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70364	METAP2/Methionine aminopeptidase 2 Protein, Human (Sf9, His)	P50579 (A2-Y478)	≥95%

Related Diseases

Diseases

Alias

Microsporidiosis

Infection By Microspora	Microsporidiasis
Infection By Microsporea	Infection By Microsporida
Intestinal Microsporidiosis	Microsporidia Infection
Infection By Microsporidia

Amelogenesis Imperfecta, Type Ia

Amelogenesis Imperfecta Type 1a	AI1A
Amelogenesis Imperfecta, Hypoplastic Type Ia	Amelogenesis Imperfecta Type Ia
Amelogenesis Imperfecta Hypoplastic Type Ia	Amelogenesis Imperfecta 1a

Liver Rhabdomyosarcoma

Rhabdomyosarcoma Of Liver

Amebiasis

Amoebiasis	Entamoebiasis
Chronic Intestinal Amebiasis	Amoebiasis, Unspecified
Amebic Colitis	Amoebic Enteritis
Infection Due To Entamoeba Histolytica	Amoebic Infection
Disease Due To Endamoebidae	Amoebiasis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-114196	Aclimostat	Inhibitor	≥98.0%	Phase 2
HY-14811	Beloranib	Inhibitor	/	Phase 2
HY-133016	M8891	Inhibitor	98.97%	Phase 1
HY-13731	PPI-2458	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120868	TP-004	Inhibitor	98.89%	Unkown
HY-134183	AUTAC1	Inducer	≥95.0%	Unkown
HY-128147	MetAP2-IN-1	Inhibitor	99.55%	Unkown
HY-133016A	(R)-M8891	Inhibitor	98.67%	Unkown
HY-150409	TSPO ligand-2		99.63%	Unkown
HY-P4344	Met-Gly-Pro-AMC	Inhibitor	99.69%	Unkown
HY-109188	Relzomostat	Inhibitor	/	Unkown
HY-158006	SDX-7539	Inhibitor	/	Unkown
HY-RS08350	METAP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	METAP2	MGD	MGI:1929701
Canis familiaris	METAP2	VGNC	VGNC:43168
Bos taurus	METAP2	VGNC	VGNC:31397
Felis catus	METAP2	VGNC	VGNC:63456
Macaca mulatta	METAP2	VGNC	VGNC:74518
Rattus norvegicus	METAP2	RGD	RGD:70995
Others	METAP2	NCBI

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