2. Gene
  3. NUDT5 - nudix hydrolase 5 Gene

NUDT5 - nudix hydrolase 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as YSA1; YSA1H; YSAH1; hNUDT5

Gene ID: 11164 | Gene type: protein coding

About NUDT5

Cytogenetic location: 10p14 Genomic coordinates (GRCh38): 10:12,165,330-12,195,891 (from NCBI)

This gene has 9 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 12.0), skin (RPKM 11.4) and 25 other tissues.

Summary

This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded Enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]

NUDT5 Products(3)

mRNA Protein Name
NM_001321647.2 NP_001308576.1 ADP-sugar pyrophosphatase isoform 2
NM_001321648.2 NP_001308577.1 ADP-sugar pyrophosphatase isoform 3
NM_014142.4 NP_054861.2 ADP-sugar pyrophosphatase isoform 1

NUDT5 Protein Structure

NUDIX

NUDIX: NUDIX domain (60 - 183)

  • 0
  • 100
  • 200
  • 219 a.a.
Protein Preferred Names Protein Names

ADP-sugar pyrophosphatase

8-oxo-dGDP phosphatase

Recombinant NUDT5 Proteins

Cat. No. Product Name Accession Purity
HY-P76525 NUDT5 Protein, Human (His) Q9UKK9 (E2-F219) ≥95%

Related Diseases

Diseases Alias
Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures

CONDSIAS

Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16965 TH287 Inhibitor 98.29% Unkown
HY-125209 TH5427 99.61% Unkown
HY-125209A TH5427 hydrochloride Inhibitor / Unkown
HY-RS09673 NUDT5 Human Pre-designed siRNA Set A / Unkown
HY-16965A TH287 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NUDT5 VGNC VGNC:32339
Canis familiaris NUDT5 VGNC VGNC:44034
Rattus norvegicus NUDT5 RGD RGD:1359284
Macaca mulatta NUDT5 VGNC VGNC:75552
Mus musculus NUDT5 MGD MGI:1858232
Others NUDT5 NCBI