CA5B - carbonic anhydrase 5B Gene

Also Known as CAVB; CA-VB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11238

About CA5B

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:15,738,270-15,788,411 (from NCBI)

This gene has 10 transcripts (splice variants), 218 orthologues and 14 paralogues. Broad expression in testis (RPKM 4.8), ovary (RPKM 2.8) and 24 other tissues.

Summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes Carbonic Anhydrase 5B. CA5B, and the related CA5A gene, has its expression localized in the mitochondria though CA5B has a wider tissue distribution than CA5A, which is restricted to the liver, kidneys, and skeletal muscle. A Carbonic Anhydrase pseudogene (CA5BP1) is adjacent to the CA5B gene and these two loci produce CA5BP1-CA5B readthrough transcripts. [provided by RefSeq, Jan 2019]

CA5B Products (1)

mRNA	Protein	Name
NM_007220.4	NP_009151.1	carbonic anhydrase 5B, mitochondrial precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables carbonate dehydratase activity	IDA IDA: Inferred from direct assay	10409679	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	10409679	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CA5B Protein Structure

Carb_anhydrase

0
100
200
300
317 a.a.

Protein Preferred Names	Protein Names
carbonic anhydrase 5B, mitochondrial	carbonate dehydratase VB

CA5B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CA5B	Q9Y2D0	DBT	Homo sapiens	P11182	Anti Tag CoIP	28514442
Intra	CA5B	Q9Y2D0	DBT	Homo sapiens	P11182	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CA5B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7721	Carbonic Anhydrase 5B Protein, Human (His)	Q9Y2D0 (C34-P317)	≥ 95%, as determined by reducing SDS-PAGE.

CA5B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811204	Carbonic Anhydrase 5B Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Carbonic Anhydrase Va Deficiency	Hyperammonemic Encephalopathy Due To Carbonic Anhydrase Va Deficiency Ca-Va Deficiency Hyperammonemia Due To Carbonic Anhydrase Va Deficiency Mitochondrial Carbonic Anhydrase Va Deficiency Ca5ad Carbonic Anhydrase Va Deficiency, Hyperammonemia Due To
Intracranial Hypertension, Idiopathic	Pseudotumor Cerebri Idiopathic Intracranial Hypertension Benign Intracranial Hypertension Iih Benign Intracran. Hypt.
External Ear Disease	Diseases Of External Ear Preauricular Cyst Preauricular Sinus And Fistula Preauricular Sinus Or Fistula
Enamel Erosion
Otitis Externa	Swimmer'S Ear Infective Otitis Externa Acute Infective Otitis Externa
Seborrheic Dermatitis	Seborrhoeic Dermatitis Seborrhea Seborrhoeic Eczema Skin Seborrheic Dermatitis, Seborrheic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01772	CA5B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CA5B	MGD	MGI:1926249
Macaca mulatta	CA5B	VGNC	VGNC:70492
Canis familiaris	CA5B	VGNC	VGNC:38613
Bos taurus	CA5B	VGNC	VGNC:26655
Rattus norvegicus	CA5B	RGD	RGD:1549783
Felis catus	CA5B	VGNC	VGNC:60276
Others	CA5B	NCBI