Acsl4 - acyl-CoA synthetase long-chain family member 4 Gene

Also Known as Acs4; Facl4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 113976

Summary

Enables arachidonate-CoA Ligase activity. Involved in several processes, including dendritic spine development; long-chain fatty-acyl-CoA biosynthetic process; and positive regulation of Insulin secretion. Located in mitochondrial membrane; neuronal cell body; and peroxisome. Colocalizes with endoplasmic reticulum. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 63. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Acsl4 Products (1)

mRNA Protein Name
NM_053623.1 NP_446075.1 long-chain-fatty-acid--CoA ligase 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arachidonate-CoA ligase activity IDA
IDA: Inferred from direct assay
28209804 RGD
enables long-chain fatty acid-CoA ligase activity IDA
IDA: Inferred from direct assay
9096315 RGD
enables long-chain fatty acid-CoA ligase activity IMP
IMP: Inferred from mutant phenotype
23766516 RGD
Biological Process GO Annotation Evidence References Source
involved in dendritic spine development IMP
IMP: Inferred from mutant phenotype
19166906 RGD
involved in fatty acid metabolic process IDA
IDA: Inferred from direct assay
9096315 RGD
involved in fatty acid transport IGI
IGI: Inferred from genetic interaction
16466685 RGD
involved in long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
28209804 RGD
involved in long-chain fatty-acyl-CoA biosynthetic process IGI
IGI: Inferred from genetic interaction
16466685 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
23766516 RGD
involved in response to interleukin-15 IEP
IEP: Inferred from expression pattern
18239634 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
16772660 RGD
involved in triglyceride biosynthetic process IGI
IGI: Inferred from genetic interaction
16466685 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
12147264 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
19166906 RGD
located in peroxisome IDA
IDA: Inferred from direct assay
12147264 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

long-chain-fatty-acid--CoA ligase 4

  • LACS 4

  • arachidonate--CoA ligase

  • fatty acid-Coenzyme A ligase, long chain 4

  • long-chain acyl-CoA synthetase 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N6707 Triacsin C Inhibitor 99.08% Unkown
HY-173432 LIBX-A401 Inhibitor 99.9% Unkown
HY-175328 LIBX-A403 Inhibitor 99.23% Unkown
HY-121246 Fluorofenidone Inhibitor 99.78% Unkown
HY-175327 LIBX-A402 Inhibitor 98.71% Unkown
HY-113167 2-Phosphoglyceric acid Inhibitor / Unkown
HY-174345 Ferroptosis inducer-8 Activator / Unkown
HY-175698 Ferroptosis inducer-9 Activator / Unkown
HY-179384 PROTAC FSP1 degrader 1 Activator / Unkown
HY-149717 Antitumor agent-122 / Unkown
HY-155851 Lepadin E Activator / Unkown
HY-183791A Ferroptosis/apoptosis inducer-5 Activator / Unkown
HY-112005G DOPE (GMP) Inhibitor / Unkown
HY-155852 Lepadin H Activator / Unkown
HY-121246S Fluorofenidone-d3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acsl4 NCBI NCBI:2182