Map2k6 - mitogen-activated protein kinase kinase 6 Gene

Also Known as Mkk6

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114495

Summary

Enables MAP kinase kinase activity. Involved in several processes, including cellular response to sorbitol; positive regulation of macromolecule metabolic process; and response to ischemia. Predicted to be located in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6). [provided by Alliance of Genome Resources, Apr 2022]

Map2k6 Products (1)

mRNA Protein Name
NM_053703.3 NP_446155.1 dual specificity mitogen-activated protein kinase kinase 6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables MAP kinase kinase activity IDA
IDA: Inferred from direct assay
20550965 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to sorbitol IEP
IEP: Inferred from expression pattern
20550965 RGD
involved in ovulation cycle process IEP
IEP: Inferred from expression pattern
11328854 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12029621 RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process IMP
IMP: Inferred from mutant phenotype
10593906 RGD
involved in positive regulation of prostaglandin secretion IMP
IMP: Inferred from mutant phenotype
12649265 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
20550965 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
20550965 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16755153 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08044 MAP2K6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17782 Map2k6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24249 Map2k6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map2k6 NCBI NCBI:5608