2. Gene
  3. MAP2K6 - mitogen-activated protein kinase kinase 6 Gene

MAP2K6 - mitogen-activated protein kinase kinase 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3

Gene ID: 5608 | Gene type: protein coding

About MAP2K6

Cytogenetic location: 17q24.3 Genomic coordinates (GRCh38): 17:69,414,697-69,553,865 (from NCBI)

This gene has 9 transcripts (splice variants), 260 orthologues and 35 paralogues. Broad expression in colon (RPKM 5.8), small intestine (RPKM 1.8) and 22 other tissues.

Summary

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and Apoptosis. [provided by RefSeq, Jul 2008]

MAP2K6 Products(2)

mRNA Protein Name
NM_001330450.2 NP_001317379.1 dual specificity mitogen-activated protein kinase kinase 6 isoform 2
NM_002758.4 NP_002749.2 dual specificity mitogen-activated protein kinase kinase 6 isoform 1

MAP2K6 Protein Structure

Pkinase

Pkinase: Protein kinase domain (57 - 314)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 6

MAPK/ERK kinase 6

Recombinant MAP2K6 Proteins

Cat. No. Product Name Accession Purity
HY-P73811 MKK6 Protein, Human (S207D, T211D, sf9, His-GST) P52564 (M1-D334, S207D, T211D) ≥95%
HY-P74745 MKK6 Protein, Human (sf9, His-GST) P52564 (M1-D334) ≥95%
HY-P74746 MKK6 Protein, Human (sf9) P52564 (N-G&P, M1-D334) ≥95%
HY-P74748 MKK6 Protein, Human (S207D, T211D, sf9) P52564 (N-G&P, M1-D334, S207D, T211D) ≥95%
HY-P700592 MAP2K6 Protein, Human (Baculovirus, His) P52564 (M1-D334) ≥95%

Related Diseases

Diseases Alias
Anthrax Disease

Anthrax

Ragpicker'S Disease

Black Baine

Malignant Edema

Malignant Pustule

Siberian Plague

Wool Sorter'S Disease

Gas Gangrene

Cutaneous Anthrax

Anthrax Infection

Splenic Fever
Retinitis Pigmentosa 38

RP38

Rod-Cone Dystrophy, Childhood-Onset

Retinitis Pigmentosa, Type 38
Cardiomyopathy, Familial Hypertrophic, 25

Hypertrophic Cardiomyopathy 25

CMH25

Cardiomyopathy, Hypertrophic, 25

Cardiomyopathy Familial Hypertrophic 25

Cardiomyopathy, Familial Hypertrophic 25

Cardiomyopathy, Hypertrophic, Type 25
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08044 MAP2K6 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MAP2K6 RGD RGD:620666
Mus musculus MAP2K6 MGD MGI:1346870
Felis catus MAP2K6 VGNC VGNC:97492
Bos taurus MAP2K6 VGNC VGNC:31187
Macaca mulatta MAP2K6 VGNC VGNC:81456
Canis familiaris MAP2K6 VGNC VGNC:42964
Others MAP2K6 NCBI