Acta2 - actin alpha 2, smooth muscle, aorta Gene

Also Known as Actvs; a-SMA; SMAalpha; SMalphaA; alphaSMA; 0610041G09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11475

Summary

The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in smooth muscle. [provided by RefSeq, Feb 2021]

Acta2 Products (1)

mRNA Protein Name
NM_007392.3 NP_031418.1 actin, aortic smooth muscle

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23055941 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21307259 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
11053242 MGI
acts upstream of or within vascular associated smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
11053242 MGI
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
17882221 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17717145 MGI
located in cytoskeleton IDA
IDA: Inferred from direct assay
16989802 MGI
located in motile cilium IDA
IDA: Inferred from direct assay
35087169 MGI
located in smooth muscle contractile fiber IDA
IDA: Inferred from direct assay
18332105 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin, aortic smooth muscle

  • actin, alpha, vascular smooth muscle

  • alpha-actin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00214 ACTA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175496 Acid Ceramidase-IN-3 Inhibitor / Unkown
HY-179410 Galectin-3-IN-7 Inhibitor / Unkown
HY-RS19169 Acta2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22375 Acta1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25658 Acta2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991219 Anti-IL11RA Antibody (X209) Inhibitor 97.75% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acta2 NCBI NCBI:59