Adk - adenosine kinase Gene

Also Known as Ak; 2310026J05Rik; 5033405D03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11534

About Adk

Chromosome 14: 21,102,642-21,498,637 forward strand.GRCm39:CM001007.3

This gene has 10 transcripts (splice variants), 275 orthologues, 3 paralogues and is associated with 34 phenotypes. Broad expression in liver adult (RPKM 33.3), liver E18 (RPKM 24.2) and 21 other tissues.

Summary

Enables Adenosine Kinase activity and deoxyadenosine kinase activity. Involved in AMP salvage; GMP salvage; and dAMP salvage. Acts upstream of or within dATP biosynthetic process and purine ribonucleoside salvage. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study fatty liver disease. Human ortholog(s) of this gene implicated in hypermethioninemia due to Adenosine Kinase deficiency. Orthologous to human ADK (Adenosine Kinase). [provided by Alliance of Genome Resources, Apr 2022]

Adk Products (2)

mRNA Protein Name
NM_134079.4 NP_598840.1 adenosine kinase isoform 1
NM_001243041.1 NP_001229970.1 adenosine kinase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables adenosine kinase activity IDA
IDA: Inferred from direct assay
718989 MGI
enables adenosine kinase activity IMP
IMP: Inferred from mutant phenotype
28751580 MGI
enables deoxyadenosine kinase activity IMP
IMP: Inferred from mutant phenotype
2835956 MGI
Biological Process GO Annotation Evidence References Source
involved in AMP salvage IDA
IDA: Inferred from direct assay
819300 MGI
involved in GMP salvage IDA
IDA: Inferred from direct assay
718989 MGI
involved in dAMP salvage IMP
IMP: Inferred from mutant phenotype
2835956 MGI
acts upstream of or within dATP biosynthetic process IMP
IMP: Inferred from mutant phenotype
12163459 MGI
acts upstream of or within purine ribonucleoside salvage IDA
IDA: Inferred from direct assay
14736855 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
819300 MGI
located in cytosol IDA
IDA: Inferred from direct assay
6407470 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14736855 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adk Protein Structure

ribokinase_pfkB_like

ribokinase_pfkB_like: cl00192 (27 - 359)

  • 0
  • 100
  • 200
  • 300
  • 361 a.a.
Protein Preferred Names Protein Names

adenosine kinase

  • adenosine 5'-phosphotransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P2952 Recombinant myokinase, Rabbit muscle / Unkown
HY-RS00505 AK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145654 MRS-4203 Inhibitor / Unkown
HY-RS00383 ADK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00384 Adk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00385 Adk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adk NCBI NCBI:132