RASGRP4 - RAS guanyl releasing protein 4 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115727

About RASGRP4

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,409,058-38,426,219 (from NCBI)

This gene has 20 transcripts (splice variants), 182 orthologues and 24 paralogues. Biased expression in bone marrow (RPKM 11.0), appendix (RPKM 5.5) and 13 other tissues.

Summary

The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated Ras protein, and the Ras activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

RASGRP4 Products (7)

mRNA Protein Name
NM_001146202.2 NP_001139674.1 RAS guanyl-releasing protein 4 isoform b
NM_001146203.2 NP_001139675.1 RAS guanyl-releasing protein 4 isoform c
NM_001146204.2 NP_001139676.1 RAS guanyl-releasing protein 4 isoform d
NM_001146205.2 NP_001139677.1 RAS guanyl-releasing protein 4 isoform e
NM_001146206.2 NP_001139678.1 RAS guanyl-releasing protein 4 isoform f
NM_001146207.2 NP_001139679.1 RAS guanyl-releasing protein 4 isoform g
NM_170604.3 NP_733749.1 RAS guanyl-releasing protein 4 isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
11880369 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
11956218 GOA
located in cytosol IDA
IDA: Inferred from direct assay
11956218 GOA
located in membrane IDA
IDA: Inferred from direct assay
11880369 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASGRP4 Protein Structure

RasGEF

RasGEF: RasGEF domain (200 - 372)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (541 - 592)

  • 0
  • 200
  • 400
  • 600
  • 673 a.a.
Protein Preferred Names Protein Names

RAS guanyl-releasing protein 4

  • guanyl nucleotide releasing protein 4

RASGRP4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89641 RasGRP4 Antibody (YA8985) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Mast-Cell Leukemia

  • Mast Cell Leukemia

  • Leukemia, Mast-Cell

  • Leukemia Mast Cell

  • Mast Cell Leukaemia Nos

  • Mast Cell Leukaemia Without Mention Of Remission
Mastocytosis

  • Mast Cell Disease

  • Mast Cell Hyperplasia

  • Urticaria Pigmentosa

  • Malignant Mastocytoma

  • Malignant Mast Cell Tumours

  • Malignant Mastocytosis
Deafness, Autosomal Recessive 97

  • DFNB97

  • Autosomal Recessive Nonsyndromic Deafness 97

  • Autosomal Recessive Deafness 97

  • Deafness, Autosomal Recessive, 97

  • Deafness, Autosomal Recessive, Type 97
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Drug-Induced Lupus Erythematosus

  • Dile

  • Dil

  • Drug-Induced Systemic Lupus Erythematosus
Congenital Disorder Of Glycosylation, Type Iii

  • CDG2I

  • Congenital Disorder Of Glycosylation Type Iii

  • Cdgiii

  • Carbohydrate Deficient Glycoprotein Syndrome Type Iii

  • Congenital Disorder Of Glycosylation Type 2i

  • Cog5-Cdg

  • Cdgiidi

  • Congenital Disorder Of Glycosylation 2i

  • Glycosylation, Congenital Disorder Of, Type Iii

  • Congenital Disorder Of Glycosylation, Type I-Iix
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11696 RASGRP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RASGRP4 VGNC VGNC:64503
Mus musculus RASGRP4 MGD MGI:2386851
Macaca mulatta RASGRP4 VGNC VGNC:76509
Bos taurus RASGRP4 VGNC VGNC:33750
Rattus norvegicus RASGRP4 RGD RGD:620476
Others RASGRP4 NCBI