CKS2 - CDC28 protein kinase regulatory subunit 2 Gene

Also Known as CKSHS2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1164

About CKS2

Cytogenetic location: 9q22.2 Genomic coordinates (GRCh38): 9:89,311,195-89,316,703 (from NCBI)

This gene has 1 transcript (splice variant), 183 orthologues and 2 paralogues. Broad expression in testis (RPKM 88.8), bone marrow (RPKM 46.4) and 21 other tissues.

Summary

CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]

CKS2 Products (1)

mRNA Protein Name
NM_001827.3 NP_001818.1 cyclin-dependent kinases regulatory subunit 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
2227411 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CKS2 Protein Structure

CKS

CKS: Cyclin-dependent kinase regulatory subunit (5 - 73)

  • 0
  • 79 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinases regulatory subunit 2

  • CDC28 protein kinase 2

CKS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CKS2 P33552 CDK3 Homo sapiens Q00526
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Coffin-Siris Syndrome 1

  • Coffin-Siris Syndrome

  • Fifth Digit Syndrome

  • Css

  • CSS1

  • Mrd12

  • Mental Retardation, Autosomal Dominant 12

  • Hhid

  • Dwarfism-Onychodysplasia

  • Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features

  • Autosomal Dominant Mental Retardation 12

  • Short Stature-Onychodysplasia.

  • Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx

  • Mental Retardation With Hypoplastic Fifth Fingernails And Toenails

  • Short Stature-Onychodysplasia

  • Coffin-Siris Syndrome, Type 1

  • Mental Retardation, Autosomal Dominant, Type 12
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02743 CKS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19311 Cks2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25802 Cks2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CKS2 MGD MGI:1913447
Felis catus CKS2 VGNC VGNC:97381
Bos taurus CKS2 VGNC VGNC:27388
Rattus norvegicus CKS2 RGD RGD:1562047
Canis familiaris CKS2 VGNC VGNC:39293
Macaca mulatta CKS2 VGNC VGNC:104887
Others CKS2 NCBI