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Lpar1 - lysophosphatidic acid receptor 1 Gene

Also Known as Edg2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 116744

About Lpar1

Primary_assembly 5: 73,229,625-73,369,895 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 216 orthologues, 18 paralogues and is associated with 15 phenotypes. Biased expression in Brain (RPKM 71.1), Uterus (RPKM 44.2) and 8 other tissues.

Summary

Enables G-protein alpha-subunit binding activity and phospholipid binding activity. Involved in several processes, including cellular response to 1-oleoyl-sn-glycerol 3-phosphate; negative regulation of cAMP-mediated signaling; and nervous system development. Located in several cellular components, including dendrite; neuronal cell body; and plasma membrane. Used to study hepatocellular carcinoma and transient cerebral ischemia. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Lpar1 Products (1)

mRNA	Protein	Name
NM_053936.4	NP_446388.1	lysophosphatidic acid receptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G-protein alpha-subunit binding	IMP IMP: Inferred from mutant phenotype	16504475	RGD
enables phospholipid binding	IMP IMP: Inferred from mutant phenotype	16504475	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16504475	RGD
involved in cellular response to 1-oleoyl-sn-glycerol 3-phosphate	IMP IMP: Inferred from mutant phenotype	12139919	RGD
involved in cellular response to oxygen levels	IEP IEP: Inferred from expression pattern	18978343	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	9753172	RGD
involved in corpus callosum development	IEP IEP: Inferred from expression pattern	9753172	RGD
involved in myelination	IEP IEP: Inferred from expression pattern	10384882	RGD
involved in negative regulation of cAMP/PKA signal transduction	IMP IMP: Inferred from mutant phenotype	12139919	RGD
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	18978343	RGD
involved in neurogenesis	IEP IEP: Inferred from expression pattern	9753172	RGD
involved in oligodendrocyte development	IEP IEP: Inferred from expression pattern	11948806	RGD
involved in optic nerve development	IEP IEP: Inferred from expression pattern	12139919	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16890224	RGD
involved in positive regulation of dendritic spine development	IDA IDA: Inferred from direct assay	16638019	RGD
involved in positive regulation of smooth muscle cell chemotaxis	IMP IMP: Inferred from mutant phenotype	19742132	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	EXP EXP: Inferred from Experiment	25996636	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	25996636	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IEP IEP: Inferred from expression pattern	25996636	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	25996636	RGD
involved in regulation of synaptic vesicle cycle	EXP EXP: Inferred from Experiment	25996636	RGD
involved in regulation of synaptic vesicle cycle	IDA IDA: Inferred from direct assay	25996636	RGD
involved in regulation of synaptic vesicle cycle	IEP IEP: Inferred from expression pattern	25996636	RGD
involved in regulation of synaptic vesicle cycle	IMP IMP: Inferred from mutant phenotype	25996636	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	EXP EXP: Inferred from Experiment	25996636	RGD
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	25996636	RGD
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	25996636	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	16638019	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	16638019	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	25996636	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25996636	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25996636	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	11948806	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	25996636	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	25996636	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Lpar1 Protein Structure

7tmA_LPAR1_Edg2

0
100
200
300
364 a.a.

Protein Preferred Names	Protein Names
lysophosphatidic acid receptor 1	LPA receptor 1 LPA-1 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 lysophosphatidic acid receptor Edg-2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16039	AM095	Antagonist	99.72%	Unkown
HY-15706	H2L 5765834	Antagonist	98.66%	Unkown
HY-117444	ONO-9780307	Inhibitor	99.94%	Unkown
HY-117959	TAK-615	Inhibitor	98.07%	Unkown
HY-115450	ONO-0300302	Antagonist	98.02%	Unkown
HY-124072	HL001	Antagonist	98.90%	Unkown
HY-181931	Autotaxin-IN-8	Inhibitor	/	Unkown
HY-178845	Decyl phosphate	Modulator	/	Unkown
HY-W725737	BrP-LPA	Antagonist	/	Unkown
HY-148291	BrP-LPA sodium	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lpar1	NCBI	NCBI:1902