Ptpn2 - protein tyrosine phosphatase, non-receptor type 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117063

Summary

Enables non-membrane spanning protein tyrosine Phosphatase activity. Predicted to be involved in several processes, including hemopoiesis; negative regulation of leukocyte differentiation; and regulation of signal transduction. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and protein dephosphorylation. Predicted to be located in several cellular components, including endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; and nucleoplasm. Predicted to colocalize with plasma membrane. Orthologous to human PTPN2 (protein tyrosine Phosphatase non-receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn2 Products (2)

mRNA Protein Name
NM_001414231.1 NP_001401160.1 tyrosine-protein phosphatase non-receptor type 2 isoform 2
NM_053990.3 NP_446442.1 tyrosine-protein phosphatase non-receptor type 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables non-membrane spanning protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
8534367 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein phosphatase non-receptor type 2

  • protein-tyrosine phosphatase PTP-S

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-145923 Osunprotafib Inhibitor 99.43% Phase 1

Pre-clinical Phase

Bioactive Molecules (25)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148691 PROTAC PTPN2 degrader-1 Degrader / Unkown
HY-153446 Tegeprotafib Inhibitor 99.30% Unkown
HY-162428 PTPN2/1-IN-3 Inhibitor 99.89% Unkown
HY-149760 PVD-06 Inhibitor 98.30% Unkown
HY-153638 PTPN2/1-IN-2 Antagonist 99.56% Unkown
HY-RS11421 PTPN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145923B Osunprotafib hydrochloride Inhibitor / Unkown
HY-153938 PROTAC PTPN2 degrader-2 / Unkown
HY-153938A PROTAC PTPN2 degrader-2 TFA / Unkown
HY-156606 Anticancer agent 142 Inhibitor / Unkown
HY-156607 Anticancer agent 143 Inhibitor / Unkown
HY-156608 Anticancer agent 144 Inhibitor / Unkown
HY-163596 PTPN2-IN-1 Inhibitor / Unkown
HY-168691 PTPN2 ligand 1 Ligand / Unkown
HY-175618 PTPN2 ligand 2 Ligand / Unkown
HY-175619 PTPN2 ligand-Linker Conjugate 1 Ligand / Unkown
HY-178716 PTPN2/1-IN-4 / Unkown
HY-179380 PTPN2-IN-2 / Unkown
HY-181255 PTPN2-IN-3 Inhibitor / Unkown
HY-183937A PD-305 / Unkown
HY-184259 PTPN2 ligand 4 Degrader / Unkown
HY-W585105 PTPN2 ligand 3 Ligand / Unkown
HY-W733139 3-[2-Oxo-6-(4-Pip)-Bz[cd]indol-1-yl]-Pip-2,6-dione / Unkown
HY-RS16588 Ptpn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23023 Ptpn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptpn2 NCBI NCBI:5771