Arg1 - arginase, liver Gene

Also Known as AI; PGIF; Arg-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11846

Summary

Enables Arginase activity. Involved in defense response to protozoan; negative regulation of T-helper 2 cell cytokine production; and negative regulation of activated T cell proliferation. Predicted to be located in several cellular components, including extracellular space; mitochondrial outer membrane; and neuronal cell body. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study hyperargininemia. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (Arginase 1). [provided by Alliance of Genome Resources, Apr 2022]

Arg1 Products (1)

mRNA Protein Name
NM_007482.3 NP_031508.1 arginase-1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables arginase activity IDA
IDA: Inferred from direct assay
9502196 MGI
Biological Process GO Annotation Evidence References Source
involved in defense response to protozoan IMP
IMP: Inferred from mutant phenotype
19360123 MGI
involved in negative regulation of T-helper 2 cell cytokine production IMP
IMP: Inferred from mutant phenotype
19360123 MGI
involved in negative regulation of activated T cell proliferation IMP
IMP: Inferred from mutant phenotype
19360123 MGI
acts upstream of or within response to nematode IDA
IDA: Inferred from direct assay
26644468 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

arginase-1

  • arginase 1, liver

  • arginase I

  • liver-type arginase

  • type I arginase

Recombinant Arg1 Proteins

Cat. No. Product Name Accession Purity
HY-P71833 Arginase-1/ARG1 Protein, Mouse (P.pastoris, His) Q61176 (M1-K323) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-123823 Nitroaspirin 98.57% Phase 2

Pre-clinical Phase

Bioactive Molecules (29)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100742A (R)-GNE-140 Inhibitor 99.77% Unkown
HY-145331A ARG1-IN-1 hydrochloride Inhibitor 90.0% Unkown
HY-103544 [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 98.48% Unkown
HY-N14001 Naamidine J 99.41% Unkown
HY-169859 EP4 receptor antagonist 7 Antagonist 99.9% Unkown
HY-P1490 Bradykinin (2-9) Modulator 97.15% Unkown
HY-RS00907 ARG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145331 ARG1-IN-1 Inhibitor / Unkown
HY-161061 Arginase inhibitor 7 Inhibitor / Unkown
HY-163426S AFFGHYLYEVAR-(Arg-13C6,15N4) / Unkown
HY-182719 AZD0011 Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-N11451 Lacto-N-fucopentaose III Activator 96.54% Unkown
HY-P11405 [D-Arg1,D-Trp5,7,9,Leu11]-Substance P Antagonist / Unkown
HY-P11882 SYN1436 Antagonist / Unkown
HY-P3225 (D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate Antagonist / Unkown
HY-P3880 (D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P Antagonist / Unkown
HY-P3881 (D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P Antagonist / Unkown
HY-P6421S LGPLVEQG-Arg(13C6,15N4) TFA / Unkown
HY-P6422S LAVYQAGA-Arg(13C6,15N4) TFA / Unkown
HY-P6423S CLAVYQAGA-Arg(13C6,15N4) TFA / Unkown
HY-P6424S LGADMEDVCG-Arg(13C6,15N4) TFA / Unkown
HY-RS14543 TINAGL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-100742AR (R)-GNE-140 (Standard) Inhibitor / Unkown
HY-173452 DT-23 Inhibitor / Unkown
HY-P6425S LCADMEDV-Arg(13C6,15N4) TFA / Unkown
HY-RS17033 Arg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18727 Tinagl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23477 Arg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991870 Anti-Arginase-1 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arg1 NCBI NCBI:383