Atf2 - activating transcription factor 2 Gene

Also Known as mXBP; Atf-2; Creb2; CRE-BP; D130078H02Rik; Tg(Gzma-Klra1)7Wum

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11909

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and protein dimerization activity. Involved in several processes, including animal organ development; histone acetylation; and intracellular signal transduction. Acts upstream of or within with a positive effect on regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adipose tissue development; fat cell differentiation; and positive regulation of transforming growth factor beta2 production. Located in membrane; nucleus; and site of double-strand break. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and musculoskeletal system. Used to study meconium aspiration syndrome and osteochondrodysplasia. Orthologous to human ATF2 (activating transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Atf2 Products (10)

mRNA Protein Name
NM_001025093.2 NP_001020264.1 cyclic AMP-dependent transcription factor ATF-2 isoform 1
NM_001284369.1 NP_001271298.1 cyclic AMP-dependent transcription factor ATF-2 isoform 2
NM_001284370.1 NP_001271299.1 cyclic AMP-dependent transcription factor ATF-2 isoform 4
NM_001284371.1 NP_001271300.1 cyclic AMP-dependent transcription factor ATF-2 isoform 4
NM_001284372.1 NP_001271301.1 cyclic AMP-dependent transcription factor ATF-2 isoform 5
NM_001284373.1 NP_001271302.1 cyclic AMP-dependent transcription factor ATF-2 isoform 5
NM_001284374.1 NP_001271303.1 cyclic AMP-dependent transcription factor ATF-2 isoform 6
NM_001284376.1 NP_001271305.1 cyclic AMP-dependent transcription factor ATF-2 isoform 3
NM_009715.3 NP_033845.1 cyclic AMP-dependent transcription factor ATF-2 isoform 2
NM_001284373.1 NP_001271302.1 cyclic AMP-dependent transcription factor ATF-2 isoform 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12220541 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
19948881 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16405968 MGI
enables cAMP response element binding IDA
IDA: Inferred from direct assay
11231009 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
17767158 MGI
enables leucine zipper domain binding IPI
IPI: Inferred from physical interaction
11231009 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
18802055 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
2138707 MGI
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
11231009 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
2138707 MGI
enables sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
15916964 MGI
Biological Process GO Annotation Evidence References Source
involved in BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
19948881 MGI
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
15916964 MGI
involved in JNK cascade IMP
IMP: Inferred from mutant phenotype
18802055 MGI
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
18802055 MGI
involved in NK T cell differentiation IMP
IMP: Inferred from mutant phenotype
16223777 MGI
involved in abducens nucleus development IMP
IMP: Inferred from mutant phenotype
21533046 MGI
acts upstream of or within adipose tissue development IGI
IGI: Inferred from genetic interaction
19948881 MGI
involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
17189429 MGI
involved in apoptotic process involved in development IMP
IMP: Inferred from mutant phenotype
21533046 MGI
involved in brainstem development IMP
IMP: Inferred from mutant phenotype
21533046 MGI
involved in cellular lipid metabolic process IMP
IMP: Inferred from mutant phenotype
21533046 MGI
involved in cellular response to anisomycin IDA
IDA: Inferred from direct assay
19584270 MGI
involved in cellular response to anisomycin IMP
IMP: Inferred from mutant phenotype
17189429 MGI
acts upstream of or within positive effect cellular response to leucine starvation IMP
IMP: Inferred from mutant phenotype
21533046 MGI
involved in cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
17699753 MGI
involved in cellular response to virus IDA
IDA: Inferred from direct assay
18802055 MGI
involved in detection of cell density IMP
IMP: Inferred from mutant phenotype
17189429 MGI
involved in facial nucleus development IMP
IMP: Inferred from mutant phenotype
21533046 MGI
involved in gene expression IDA
IDA: Inferred from direct assay
16405968 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
18638549 MGI
involved in growth plate cartilage chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
18638549 MGI
involved in growth plate cartilage chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
18638549 MGI
involved in heart development IGI
IGI: Inferred from genetic interaction
17699753 MGI
involved in hematopoietic progenitor cell differentiation IGI
IGI: Inferred from genetic interaction
17699753 MGI
involved in hepatocyte apoptotic process IGI
IGI: Inferred from genetic interaction
17699753 MGI
involved in hypoglossal nucleus development IMP
IMP: Inferred from mutant phenotype
21533046 MGI
involved in in utero embryonic development IGI
IGI: Inferred from genetic interaction
17699753 MGI
involved in in utero embryonic development IMP
IMP: Inferred from mutant phenotype
17699753 MGI
involved in intrinsic apoptotic signaling pathway in response to hypoxia IMP
IMP: Inferred from mutant phenotype
17189429 MGI
involved in liver development IGI
IGI: Inferred from genetic interaction
17699753 MGI
involved in mRNA transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18638549 MGI
involved in motor neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
21533046 MGI
involved in neurofilament cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21533046 MGI
acts upstream of or within outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
17767158 MGI
involved in p38MAPK cascade IGI
IGI: Inferred from genetic interaction
17699753 MGI
involved in p38MAPK cascade IMP
IMP: Inferred from mutant phenotype
19948881 MGI
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16405968 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9748258 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19948881 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
9748258 MGI
acts upstream of or within positive regulation of transforming growth factor beta2 production IMP
IMP: Inferred from mutant phenotype
17767158 MGI
involved in protein import into nucleus IDA
IDA: Inferred from direct assay
32385399 MGI
involved in regulation of cell cycle checkpoint IMP
IMP: Inferred from mutant phenotype
18638549 MGI
acts upstream of or within positive effect regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11231009 MGI
involved in response to organic cyclic compound IMP
IMP: Inferred from mutant phenotype
18227516 MGI
involved in vacuole organization IMP
IMP: Inferred from mutant phenotype
21533046 MGI
acts upstream of or within white fat cell differentiation IGI
IGI: Inferred from genetic interaction
19948881 MGI
involved in white fat cell differentiation IGI
IGI: Inferred from genetic interaction
19948881 MGI
involved in white fat cell differentiation IMP
IMP: Inferred from mutant phenotype
19948881 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
15030387 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19948881 MGI
located in site of double-strand break IMP
IMP: Inferred from mutant phenotype
15916964 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclic AMP-dependent transcription factor ATF-2

  • cAMP response element-binding protein CRE-BP1

  • cAMP-dependent transcription factor ATF-2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1198 Piperonyl butoxide Inhibitor 98.0% Unkown
HY-B1198R Piperonyl butoxide (Standard) Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-13241A Ralimetinib Inhibitor 98.58% Phase 2
HY-152860 Darizmetinib 99.94% Phase 1

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13241 Ralimetinib dimesylate 99.97% Unkown
HY-134963 SBI-0087702 99.55% Unkown
HY-117987 CPS-11 99.39% Unkown
HY-B1198S Piperonyl butoxide-d9 Inhibitor 98.68% Unkown
HY-RS01128 ATF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W585976 Benzo[a]pyrene diol epoxide / Unkown
HY-180419 SF-3-030 / Unkown
HY-RS05361 GDNF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-107091R Aspartyl-alanyl-diketopiperazine (Standard) Inhibitor / Unkown
HY-RS17003 Atf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23446 Atf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atf2 NCBI NCBI:1386