Bcl3 - B cell leukemia/lymphoma 3 Gene

Also Known as Bcl-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12051

Summary

Enables transcription coactivator activity. Acts upstream of or within several processes, including defense response to Other organism; hematopoietic or lymphoid organ development; and regulation of gene expression. Predicted to be located in several cellular components, including cytosol; midbody; and nucleoplasm. Predicted to be part of Bcl3-Bcl10 complex and Bcl3/NF-kappaB2 complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; immune system; and liver and biliary system. Orthologous to human BCL3 (BCL3 transcription coactivator). [provided by Alliance of Genome Resources, Apr 2022]

Bcl3 Products (1)

mRNA Protein Name
NM_033601.3 NP_291079.2 B-cell lymphoma 3 protein homolog

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12730195 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
16081776 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of T cell apoptotic process IGI
IGI: Inferred from genetic interaction
16832056 MGI
acts upstream of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16832056 MGI
acts upstream of or within T-helper 1 type immune response IMP
IMP: Inferred from mutant phenotype
9009202 MGI
acts upstream of or within T-helper 2 cell differentiation IMP
IMP: Inferred from mutant phenotype
16081776 MGI
acts upstream of or within antimicrobial humoral response IMP
IMP: Inferred from mutant phenotype
9009202 MGI
acts upstream of or within defense response to bacterium IMP
IMP: Inferred from mutant phenotype
9009202 MGI
acts upstream of or within defense response to protozoan IMP
IMP: Inferred from mutant phenotype
9009202 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
10586052 MGI
acts upstream of or within follicular dendritic cell differentiation IMP
IMP: Inferred from mutant phenotype
10586052 MGI
acts upstream of or within germinal center formation IMP
IMP: Inferred from mutant phenotype
9009202 MGI
acts upstream of or within humoral immune response mediated by circulating immunoglobulin IMP
IMP: Inferred from mutant phenotype
9009202 MGI
acts upstream of or within marginal zone B cell differentiation IMP
IMP: Inferred from mutant phenotype
9009202 MGI
acts upstream of or within negative regulation of T cell apoptotic process IGI
IGI: Inferred from genetic interaction
16832056 MGI
acts upstream of or within negative regulation of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16832056 MGI
acts upstream of or within negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
15465827 MGI
acts upstream of or within positive regulation of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
15465827 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16081776 MGI
acts upstream of or within positive regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
16790793 MGI
acts upstream of or within spleen development IMP
IMP: Inferred from mutant phenotype
10586052 MGI
acts upstream of type II interferon production IMP
IMP: Inferred from mutant phenotype
16790793 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

B-cell lymphoma 3 protein homolog

  • B-cell CLL/lymphoma 3

Bcl3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Bcl3 Q9Z2F6 Cyld Mus musculus Q80TQ2
Anti Bait CoIP
16713561
Intra
Bcl3 Q9Z2F6 Cyld Mus musculus Q80TQ2
Y2H
16713561
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111152 ML115 Agonist 99.98% Unkown
HY-152177 JS6 Inhibitor 99.49% Unkown
HY-14454 TPh A 99.75% Unkown
HY-RS01437 BCL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18602 Bcl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25087 Bcl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl3 NCBI NCBI:602