Cyld - CYLD lysine 63 deubiquitinase Gene

Also Known as EAC; CDMT; CYLD1; mKIAA0849; 2010013M14Rik; 2900009M21Rik; C130039D01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74256

Summary

This gene encodes a protein that is a member of the ubiquitin C-terminal hydrolase subfamily of the deubiquitinating enzyme family. Members of this family catalyze the removal of ubiquitin from a substrate or another ubiquitin molecule and thereby play important roles in regulating signaling pathways, recycling ubiquitin and regulating protein stability. This protein removes ubiquitin from K-63-linked ubiquitin chains from proteins involved in NF-kappaB signaling and thus acts as a negative regulator of this pathway. In humans mutations in this gene have been associated with cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. In mouse deficiency of this gene impairs thymocyte development and increases susceptibility to skin and colon tumors. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Cyld Products (4)

mRNA Protein Name
NM_001128170.2 NP_001121642.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform a
NM_001128171.2 NP_001121643.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform b
NM_001276279.1 NP_001263208.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform c
NM_173369.3 NP_775545.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables K48-linked deubiquitinase activity IDA
IDA: Inferred from direct assay
16501569 MGI
enables K63-linked deubiquitinase activity IDA
IDA: Inferred from direct assay
16501569 MGI
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
28701375 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16501569 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IMP
IMP: Inferred from mutant phenotype
16501569 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
16501569 MGI
acts upstream of or within necroptotic process IGI
IGI: Inferred from genetic interaction
21052097 MGI
acts upstream of or within necroptotic process IMP
IMP: Inferred from mutant phenotype
27545878 MGI
involved in negative regulation of JNK cascade IDA
IDA: Inferred from direct assay
29291351 MGI
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
32424362 MGI
involved in negative regulation of interleukin-18-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
32424362 MGI
involved in negative regulation of p38MAPK cascade IDA
IDA: Inferred from direct assay
29291351 MGI
acts upstream of or within positive regulation of T cell differentiation IMP
IMP: Inferred from mutant phenotype
16501569 MGI
acts upstream of or within positive regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16501569 MGI
acts upstream of or within positive regulation of protein localization IDA
IDA: Inferred from direct assay
16501569 MGI
involved in protein K63-linked deubiquitination IDA
IDA: Inferred from direct assay
29291351 MGI
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
29291351 MGI
acts upstream of or within protein deubiquitination IMP
IMP: Inferred from mutant phenotype
22037414 MGI
involved in protein linear deubiquitination IDA
IDA: Inferred from direct assay
28701375 MGI
acts upstream of or within regulation of B cell differentiation IMP
IMP: Inferred from mutant phenotype
16501569 MGI
involved in regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
25134987 MGI
involved in regulation of necroptotic process IDA
IDA: Inferred from direct assay
28701375 MGI
acts upstream of or within regulation of protein binding IDA
IDA: Inferred from direct assay
16501569 MGI
involved in regulation of tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
28701375 MGI
acts upstream of or within ripoptosome assembly involved in necroptotic process IMP
IMP: Inferred from mutant phenotype
22037414 MGI
Cellular Component GO Annotation Evidence References Source
located in ciliary basal body IDA
IDA: Inferred from direct assay
25134987 MGI
located in ciliary tip IDA
IDA: Inferred from direct assay
25134987 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase CYLD

  • cylindromatosis (turban tumor syndrome)

  • deubiquitinating enzyme CYLD

  • ubiquitin thioesterase CYLD

  • ubiquitin thiolesterase CYLD

  • ubiquitin-specific-processing protease CYLD

Cyld Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cyld Q80TQ2 Hdac6 Mus musculus Q9Z2V5
Fluorescence
19893491
Intra
Cyld Q80TQ2 Tuba1a Mus musculus P68369
Fluorescence
19893491
Intra
Cyld Q80TQ2 Tuba1a Mus musculus P68369
Anti Bait CoIP
19893491
Intra
Cyld Q80TQ2 Itch Mus musculus Q8C863
Anti Bait CoIP
22057290
Intra
Cyld Q80TQ2 Bcl3 Mus musculus Q9Z2F6
Anti Bait CoIP
19893491
Intra
Cyld Q80TQ2 Bcl3 Mus musculus Q9Z2F6
IF
16713561
Intra
Cyld Q80TQ2 Bcl3 Mus musculus Q9Z2F6
Y2H
16713561
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-176426 Subquinocin 99.83% Phase 4
HY-19704 Pegcantratinib Antagonist / Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03433 CYLD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17882 Cyld Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24351 Cyld Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyld NCBI NCBI:1540