Itch - itchy, E3 ubiquitin protein ligase Gene

Also Known as AIP4; A130065M08; 6720481N21Rik; 8030492O04Rik; C230047C07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16396

Summary

Enables Ligase activity. Involved in several processes, including negative regulation of JNK cascade; negative regulation of NF-kappaB transcription factor activity; and protein K48-linked ubiquitination. Acts upstream of or within several processes, including cellular protein metabolic process; negative regulation of alpha-beta T cell proliferation; and positive regulation of T cell anergy. Located in several cellular components, including cell cortex; cytoplasmic vesicle; and nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human ITCH (itchy E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Itch Products (2)

mRNA Protein Name
NM_001243712.1 NP_001230641.1 E3 ubiquitin-protein ligase Itchy
NM_008395.3 NP_032421.2 E3 ubiquitin-protein ligase Itchy

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ligase activity IMP
IMP: Inferred from mutant phenotype
18246070 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11782481 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of CD4-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
14973438 MGI
acts upstream of T cell anergy IMP
IMP: Inferred from mutant phenotype
14973438 MGI
acts upstream of or within negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
14973438 MGI
involved in negative regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
18246070 MGI
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
18246070 MGI
involved in negative regulation of defense response to virus IMP
IMP: Inferred from mutant phenotype
19881509 MGI
acts upstream of or within positive regulation of T cell anergy IMP
IMP: Inferred from mutant phenotype
14973438 MGI
acts upstream of or within positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
14973438 MGI
acts upstream of or within positive regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
14973438 MGI
involved in protein K48-linked ubiquitination IMP
IMP: Inferred from mutant phenotype
18246070 MGI
acts upstream of protein catabolic process IMP
IMP: Inferred from mutant phenotype
14973438 MGI
acts upstream of or within protein polyubiquitination IDA
IDA: Inferred from direct assay
14973438 MGI
involved in regulation of protein deubiquitination IMP
IMP: Inferred from mutant phenotype
18246070 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
14973438 MGI
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
17137798 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
14973438 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
17137798 MGI
located in membrane IDA
IDA: Inferred from direct assay
14973438 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11555636 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase Itchy

  • HECT-type E3 ubiquitin transferase Itchy homolog

Itch Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Itch Q8C863 Cyld Mus musculus Q80TQ2
Anti Bait CoIP
22057290
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0548A Hydroxyzine dihydrochloride Antagonist 99.59% Unkown
HY-B0548 Hydroxyzine Antagonist 99.72% Unkown
HY-B1183 Hydrocortisone acetate Agonist 99.07% Yes
HY-A0075 Decloxizine dihydrochloride Antagonist 99.69% Unkown
HY-B1173 (+)-Camphor Inhibitor 99.51% Unkown
HY-106566 Alclometasone dipropionate ≥96.0% Unkown
HY-17582 Decloxizine Antagonist 99.80% Unkown
HY-P3445 Anrikefon Agonist / Unkown
HY-17582R Decloxizine (Standard) Antagonist / Unkown
HY-A0075R Decloxizine dihydrochloride (Standard) Antagonist / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99025 Lebrikizumab Inhibitor 99.90% Unkown
HY-P99162 Nemolizumab Inhibitor 99.70% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-145153 S-777469 Agonist 98.19% Phase 2
HY-14939 Vapitadine 99.77% Phase 2
HY-W665882 Norketotifen Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-129047 Trypsin Activator 91.00% Unkown
HY-129047A Trypsin (MS grade) Activator 95.00% Unkown
HY-118069 (R)-ZINC-3573 Agonist 99.83% Unkown
HY-103368 Eact Activator 98.86% Unkown
HY-148949 Kallikrein 5-IN-2 99.46% Unkown
HY-165559 Trpvicin Inhibitor 99.4% Unkown
HY-148244 MS47134 99.69% Unkown
HY-147051 Nelremagpran 99.94% Unkown
HY-103320A Calhex 231 hydrochloride Inhibitor 99.81% Unkown
HY-145997 MRGPRX4 modulator-1 98.96% Unkown
HY-B1144A Chlormidazole hydrochloride Inhibitor 99.45% Unkown
HY-143481 Nav1.8-IN-2 Inhibitor 99.83% Unkown
HY-103320B (1R,2R)-Calhex 231 hydrochloride Control 98.45% Unkown
HY-171366 lirucitinib Inhibitor 98.72% Unkown
HY-108425B (Rac)-AMG8379 Antagonist 99.25% Unkown
HY-163840 GFRα2/3-IN-1 Inhibitor / Unkown
HY-153275A KM-001-E2 99.08% Unkown
HY-108425 AMG8379 Antagonist / Unkown
HY-103320 Calhex 231 Antagonist / Unkown
HY-108425A AMG8380 Inhibitor / Unkown
HY-124356 Alcaftadine carboxylic acid / Unkown
HY-124356AS Alcaftadine carboxylic acid-d3 sodium / Unkown
HY-135495 AM-0466 Inhibitor / Unkown
HY-157496 EP3 antagonist 7 Antagonist / Unkown
HY-175672 MRGPRX4 modulator-3 Modulator / Unkown
HY-182517 AG1529 Antagonist / Unkown
HY-182710 DA-0218 Inhibitor / Unkown
HY-N20319 Cynanchum paniculatum extract / Unkown
HY-P5357 SFNGGP-NH2 / Unkown
HY-RS06943 ITCH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N12040 γ-Isofagarine / Unkown
HY-RS17888 Itch Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24357 Itch Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itch NCBI NCBI:83737