Bgn - biglycan Gene

Also Known as BG; PGI; DSPG1; PG-S1; SLRR1A

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12111

Summary

This gene encodes a small, leucine-rich repeat proteoglycan that plays important roles in bone mineralization and connective tissue metabolism. The encoded preproprotein undergoes post-translational processing during which chondroitin sulfate or dermatan sulfate chains are attached before incorporation into the extracellular matrix. Mice lacking the encoded protein exhibit reduced growth rate and acquire diminished bone mass progressively with age. [provided by RefSeq, Oct 2015]

Bgn Products (2)

mRNA Protein Name
NM_001411776.1 NP_001398705.1 biglycan isoform 1 precursor
NM_007542.5 NP_031568.2 biglycan isoform 2 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables cytokine binding IPI
IPI: Inferred from physical interaction
15572151 MGI
enables extracellular matrix binding IDA
IDA: Inferred from direct assay
18757743 MGI
enables glycosaminoglycan binding IDA
IDA: Inferred from direct assay
18757743 MGI
Biological Process GO Annotation Evidence Referencias Source
acts upstream of or within articular cartilage development IGI
IGI: Inferred from genetic interaction
19932218 MGI
acts upstream of or within bone development IGI
IGI: Inferred from genetic interaction
19932218 MGI
Cellular Component GO Annotation Evidence Referencias Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
16810681 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
16810681 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
16810681 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

biglycan

  • bone/cartilage proteoglycan I

Recombinant Bgn Proteins

Referencia número Nombre del producto Accession Pureza
HY-P75477 Biglycan Protein, Mouse (HEK293, Fc) P28653 (D38-K369) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-139162 BGN3 99.55% Unkown
HY-RS01489 BGN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18113 Bgn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24587 Bgn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bgn NCBI NCBI:633