Brca1 - breast cancer 1, early onset Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12189

Summary

Enables damaged DNA binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including regulation of gene expression by genetic imprinting; regulation of histone modification; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes, including centrosome cycle; dosage compensation by inactivation of X chromosome; and mitotic G2/M transition checkpoint. Located in condensed nuclear chromosome and cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Used to study breast Cancer. Human ortholog(s) of this gene implicated in several diseases, including breast Cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system Cancer (multiple); hereditary breast ovarian Cancer syndrome; and reproductive organ Cancer (multiple). Orthologous to human BRCA1 (BRCA1 DNA repair associated). [provided by Alliance of Genome Resources, Apr 2022]

Brca1 Products (1)

mRNA Protein Name
NM_009764.3 NP_033894.3 breast cancer type 1 susceptibility protein homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity IDA
IDA: Inferred from direct assay
20820192 MGI
enables damaged DNA binding IDA
IDA: Inferred from direct assay
11934988 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
20820192 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
23271346 MGI
acts upstream of or within centrosome cycle IGI
IGI: Inferred from genetic interaction
15123655 MGI
acts upstream of or within chordate embryonic development IMP
IMP: Inferred from mutant phenotype
9171368 MGI
involved in double-strand break repair IMP
IMP: Inferred from mutant phenotype
22186889 MGI
acts upstream of or within mitotic G2/M transition checkpoint IMP
IMP: Inferred from mutant phenotype
15254237 MGI
acts upstream of positive effect negative regulation of gene expression via chromosomal CpG island methylation IDA
IDA: Inferred from direct assay
20820192 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20820192 MGI
acts upstream of or within random inactivation of X chromosome IGI
IGI: Inferred from genetic interaction
12419249 MGI
Cellular Component GO Annotation Evidence References Source
located in XY body IDA
IDA: Inferred from direct assay
31839538 MGI
located in chromosome IDA
IDA: Inferred from direct assay
22549958 MGI
located in condensed chromosome IDA
IDA: Inferred from direct assay
12913077 MGI
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
20551173 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11172592 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
31839538 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

breast cancer type 1 susceptibility protein homolog

  • RING-type E3 ubiquitin transferase BRCA1

  • breast and ovarian cancer susceptibility protein

  • breast cancer associated 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10617A Rucaparib Inhibitor 99.96% Yes
HY-114778 Fluzoparib Inhibitor 99.96% Unkown
HY-10617 Rucaparib phosphate Inhibitor 99.76% Yes
HY-102003 Rucaparib monocamsylate Inhibitor 99.91% Yes
HY-102003A Rucaparib camsylate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-125010 Dicycloplatin Inducer / Phase 3
HY-160700 TNG348 Inhibitor 99.74% Phase 2
HY-115552 Simmiparib Inhibitor 99.01% Phase 1

Pre-clinical Phase

Bioactive Molecules (44)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124691 D-I03 Inhibitor 99.70% Unkown
HY-W327122 BAP1-IN-1 Inhibitor 99.86% Unkown
HY-139156 SK-575 Inhibitor 99.86% Unkown
HY-126020 Bractoppin Inhibitor 99.90% Unkown
HY-162859 AB25583 Inhibitor 99.87% Unkown
HY-162706 BSJ-5-63 Degrader 99.97% Unkown
HY-139329 CDK12-IN-6 Inhibitor 99.15% Unkown
HY-174143 EXO1-IN-1 Inducer 99.00% Unkown
HY-W116007 Octamethylcyclotetrasiloxane Inhibitor 99.86% Unkown
HY-179289 ZLY025 99.40% Unkown
HY-100862 BRCA1-IN-2 Inhibitor 98.12% Unkown
HY-RS01593 BRCA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-139328 CDK12-IN-5 Inhibitor 98.03% Unkown
HY-181692 PROTAC RNF4 degrader-1 98.09% Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 98.66% Unkown
HY-158346 RP-2119 Inhibitor 99.94% Unkown
HY-162477 TS-24 98.96% Unkown
HY-171171 NERx 329 Inhibitor 98.77% Unkown
HY-179585 DD-CIP2 Inducer / Unkown
HY-179219S RTx-303 Inhibitor / Unkown
HY-181035 DN1679 Degrader / Unkown
HY-183630 AZD4956 Inhibitor / Unkown
HY-10617AS1 Rucaparib-d3 Inhibitor / Unkown
HY-120750 A 62176 hydrochloride / Unkown
HY-122583 D-G23 Inhibitor / Unkown
HY-132885 PARP/EZH2-IN-1 Inhibitor / Unkown
HY-139327 CDK12-IN-4 Inhibitor / Unkown
HY-14687 (rac)-Talazoparib Inhibitor / Unkown
HY-149003 PARP1-IN-10 / Unkown
HY-153755 ART6043 Inhibitor / Unkown
HY-155246 PARP1-IN-15 / Unkown
HY-155766 PARP1-IN-14 / Unkown
HY-157212 PARP-1/Proteasome-IN-1 / Unkown
HY-168094 PARP1-IN-30 Inhibitor / Unkown
HY-174446 PARP1-IN-39 Inhibitor / Unkown
HY-175257 Theophylline-platinum(IV) prodrug-1 / Unkown
HY-179582 PROTAC DNPH1 Degrader 1 Degrader / Unkown
HY-181842 PARP1/ERK IN-1 / Unkown
HY-183363 USP1-IN-17 Inhibitor / Unkown
HY-183765 PARP1/PKM2-IN-1 Inhibitor / Unkown
HY-174563 Human OLA1 mRNA / Unkown
HY-RS16661 Brca1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23096 Brca1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-100863 BRCA1-IN-1 Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990873 Anti-BRCA1 Antibody (BR64) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Brca1 NCBI NCBI:672