Btrc - beta-transducin repeat containing protein Gene

Also Known as HOS; FWD1; Fbw1a; Slimb; b-TrCP; beta-TrCP; Beta-Trcp1; SCF b-TRCP; E3RSIkappaB; E3RS-IkappaB

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12234

Summary

Enables beta-catenin binding activity; protein phosphorylated amino acid binding activity; and ubiquitin protein Ligase activity. Involved in several processes, including cellular protein metabolic process; positive regulation of circadian rhythm; and regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including mammary gland epithelium development; protein K48-linked ubiquitination; and regulation of I-kappaB kinase/NF-kappaB signaling. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; peripheral nervous system; and respiratory system. Orthologous to human BTRC (beta-transducin repeat containing E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Btrc Products (10)

mRNA Protein Name
NM_001037758.2 NP_001032847.2 F-box/WD repeat-containing protein 1A isoform a
NM_001286465.1 NP_001273394.1 F-box/WD repeat-containing protein 1A isoform a
NM_001286466.1 NP_001273395.1 F-box/WD repeat-containing protein 1A isoform c
NM_001360120.1 NP_001347049.1 F-box/WD repeat-containing protein 1A isoform d
NM_001360122.1 NP_001347051.1 F-box/WD repeat-containing protein 1A isoform e
NM_001360124.1 NP_001347053.1 F-box/WD repeat-containing protein 1A isoform f
NM_001360126.1 NP_001347055.1 F-box/WD repeat-containing protein 1A isoform g
NM_001360127.1 NP_001347056.1 F-box/WD repeat-containing protein 1A isoform h
NM_001409992.1 NP_001396921.1 F-box/WD repeat-containing protein 1A isoform f
NM_009771.3 NP_033901.1 F-box/WD repeat-containing protein 1A isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-catenin binding IDA
IDA: Inferred from direct assay
10228155 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16371461 MGI
enables protein phosphorylated amino acid binding IDA
IDA: Inferred from direct assay
10228155 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
10228155 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
32558204 MGI
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
21911472 MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
15340078 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
19103752 MGI
acts upstream of or within mammary gland epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15340078 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18782782 MGI
involved in positive regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
18782782 MGI
acts upstream of or within protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
29593216 MGI
acts upstream of or within protein catabolic process IMP
IMP: Inferred from mutant phenotype
12843402 MGI
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
18782782 MGI
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
10228155 MGI
acts upstream of or within protein ubiquitination IDA
IDA: Inferred from direct assay
32558204 MGI
acts upstream of or within regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
12843402 MGI
involved in regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
18929646 MGI
acts upstream of or within regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
12791266 MGI
acts upstream of or within regulation of proteasomal protein catabolic process IDA
IDA: Inferred from direct assay
19103752 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18929646 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18929646 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-box/WD repeat-containing protein 1A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01680 BTRC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20699 Btrc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27210 Btrc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99896 Runimotamab 99.00% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Btrc NCBI NCBI:8945