Serping1 - serine (or cysteine) peptidase inhibitor, clade G, member 1 Gene

Also Known as C1nh; C1INH

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12258

Summary

Enables complement binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of complement activation, lectin pathway and negative regulation of endopeptidase activity. Predicted to act upstream of or within several processes, including complement activation, classical pathway; fibrinolysis; and negative regulation of peptidase activity. Located in extracellular space. Is expressed in several structures, including genitourinary system; neural ectoderm; notochord; pancreas mesenchyme; and visceral pericardium. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; angioedema (multiple); cerebral infarction; pancreatitis; and toxic shock syndrome. Orthologous to human SERPING1 (Serpin family G member 1). [provided by Alliance of Genome Resources, Apr 2022]

Serping1 Products (1)

mRNA Protein Name
NM_009776.3 NP_033906.2 plasma protease C1 inhibitor precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables complement binding IPI
IPI: Inferred from physical interaction
9652403 MGI
enables serine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
9199246 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
9652403 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

plasma protease C1 inhibitor

  • C1 Inh

  • C1 esterase inhibitor

  • C1 inhibitor

  • C1-inhibiting factor

  • complement component 1 inhibitor

  • serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1

  • serine (or cysteine) proteinase inhibitor, clade G, member 1

  • serpin G1

Recombinant Serping1 Proteins

Cat. No. Product Name Accession Purity
HY-P71297 Serpin G1 Protein, Mouse (HEK293, His) P97290 (A20-G504) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12694 SERP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12727 SERPING1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18444 Serping1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24926 Serping1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Serping1 NCBI NCBI:710