C5ar1 - complement component 5a receptor 1 Gene

Also Known as C5aR; C5r1; Cd88; D7Msu1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12273

Summary

Enables complement component C5a receptor activity. Involved in several processes, including astrocyte activation; positive regulation of vascular endothelial growth factor production; and regulation of granulocyte chemotaxis. Acts upstream of or within defense response to Gram-positive bacterium; neutrophil chemotaxis; and response to peptidoglycan. Predicted to be located in several cellular components, including apical part of cell; basolateral plasma membrane; and cell surface. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; liver; neural ectoderm; and sensory organ. Orthologous to several human genes including OPRPN (opiorphin prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]

C5ar1 Products (2)

mRNA	Protein	Name
NM_001173550.1	NP_001167021.1	C5a anaphylatoxin chemotactic receptor 1
NM_007577.4	NP_031603.2	C5a anaphylatoxin chemotactic receptor 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables complement component C5a receptor activity	IDA IDA: Inferred from direct assay	1401897	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in amyloid-beta clearance	IGI IGI: Inferred from genetic interaction	19561098	MGI
involved in astrocyte activation	IGI IGI: Inferred from genetic interaction	19561098	MGI
involved in cognition	IGI IGI: Inferred from genetic interaction	19561098	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	17114491	MGI
involved in microglial cell activation	IGI IGI: Inferred from genetic interaction	19561098	MGI
acts upstream of or within neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	17114491	MGI
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	16452172	MGI
involved in positive regulation of macrophage chemotaxis	IMP IMP: Inferred from mutant phenotype	16452172	MGI
involved in positive regulation of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	16452172	MGI
involved in positive regulation of vascular endothelial growth factor production	IMP IMP: Inferred from mutant phenotype	16452172	MGI
involved in presynapse organization	IGI IGI: Inferred from genetic interaction	19561098	MGI
involved in regulation of tau-protein kinase activity	IGI IGI: Inferred from genetic interaction	19561098	MGI
acts upstream of or within response to peptidoglycan	IMP IMP: Inferred from mutant phenotype	17114491	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
C5a anaphylatoxin chemotactic receptor 1	C5a anaphylatoxin receptor C5a ligand C5a-R complement component 5, receptor 1

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-106178	PMX-53	Antagonist	99.95%	Phase 2
HY-157472	ACT-1014-6470	Antagonist	/	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99450	Avdoralimab	Inhibitor	99.25%	Phase 2
HY-P990745	Izastobart	Ligand	99%	Phase 1

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110136A	PMX 205 Trifluoroacetate	Antagonist	99.50%	Unkown
HY-148141	JPE-1375	Antagonist	99.96%	Unkown
HY-145237	BM213		99.62%	Unkown
HY-P10639	C5aR2 agonist P32	Agonist	99.17%	Unkown
HY-W157299	2-(Bromomethyl)-1-fluoro-3-methoxybenzene		/	Unkown
HY-163378	C5aR1 antagonist 1	Antagonist	/	Unkown
HY-163379	C5aR1 antagonist 2	Antagonist	/	Unkown
HY-175981	Paclitaxel-bromothiophene		/	Unkown
HY-RS01750	C5AR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P10639A	C5aR2 agonist P32 acetate	Agonist	/	Unkown
HY-RS18377	C5ar1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24857	C5ar1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W130878	4-Octylphenol	Activator	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991485	Anti-CD88/C5AR1 Antibody (G2_anti-C5aR)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	C5ar1	NCBI	NCBI:728