Cd247 - CD247 antigen Gene

Also Known as Cd3; T3z; Cd3h; Cd3z; Tcrk; Tcrz; Cd3-eta; Cd3zeta; Cd3-zeta; 4930549J05Rik; A430104F18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12503

Summary

Predicted to enable identical protein binding activity and protein tyrosine kinase binding activity. Acts upstream of or within T cell receptor signaling pathway and positive regulation of protein localization to cell surface. Located in Golgi apparatus and plasma membrane. Part of alpha-beta T cell receptor complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in immunodeficiency 25. Orthologous to human CD247 (CD247 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd247 Products (4)

mRNA Protein Name
NM_001113391.2 NP_001106862.1 CD247 antigen isoform zeta precursor
NM_001113392.2 NP_001106863.1 CD247 antigen isoform iota precursor
NM_001113393.2 NP_001106864.2 CD247 antigen isoform theta precursor
NM_031162.4 NP_112439.1 CD247 antigen isoform eta precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8196616 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
11435465 MGI
acts upstream of or within interleukin-2 production IGI
IGI: Inferred from genetic interaction
15184345 MGI
acts upstream of or within positive regulation of protein localization to cell surface IDA
IDA: Inferred from direct assay
15184345 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
24638062 MGI
part of alpha-beta T cell receptor complex IDA
IDA: Inferred from direct assay
9064344 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
24638062 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CD247 antigen

  • CD3 antigen, zeta polypeptide

  • CD3-zeta/eta

  • T-cell receptor T3 eta chain

  • T-cell surface glycoprotein CD3 zeta chain

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02214 CD247 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21508 Cd247 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28026 Cd247 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd247 NCBI NCBI:919