CD247 - CD247 molecule Gene

Also Known as T3Z; CD3H; CD3Q; CD3Z; TCRZ; IMD25; CD3ZETA; CD3-ZETA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 919

About CD247

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:167,430,640-167,518,529 (from NCBI)

This gene has 40 transcripts (splice variants), 147 orthologues and is associated with 4 phenotypes. Biased expression in lymph node (RPKM 25.8), spleen (RPKM 18.4) and 11 other tissues.

Summary

The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CD247 Products (4)

mRNA	Protein	Name
NM_000734.4	NP_000725.1	T-cell surface glycoprotein CD3 zeta chain isoform 2 precursor
NM_001378515.1	NP_001365444.1	T-cell surface glycoprotein CD3 zeta chain isoform 3 precursor
NM_001378516.1	NP_001365445.1	T-cell surface glycoprotein CD3 zeta chain isoform 4 precursor
NM_198053.3	NP_932170.1	T-cell surface glycoprotein CD3 zeta chain isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	14967045	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17055436	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	2532305	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	1825220	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	1825220	GOA
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	8681956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Fc-gamma receptor signaling pathway	IDA IDA: Inferred from direct assay	8478617	GOA
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	35271814	GOA
involved in protein complex oligomerization	EXP EXP: Inferred from Experiment	14967045	GOA
involved in protein complex oligomerization	IPI IPI: Inferred from physical interaction	14967045	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	9485181	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Fc-gamma receptor III complex	IDA IDA: Inferred from direct assay	1825220	GOA
part of T cell receptor complex	IDA IDA: Inferred from direct assay	8176201	GOA
part of alpha-beta T cell receptor complex	IDA IDA: Inferred from direct assay	9485181	GOA
part of alpha-beta T cell receptor complex	IPI IPI: Inferred from physical interaction	31461748	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11390434	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	1390434	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD247 Protein Structure

TCR_zetazeta

ITAM

0
100
164 a.a.

Protein Preferred Names	Protein Names
T-cell surface glycoprotein CD3 zeta chain	CD247 antigen, zeta subunit

CD247 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD247	P20963	ZAP70	Homo sapiens	P43403	SPR	9185620
Intra	CD247	P20963	ZAP70	Homo sapiens	P43403	ITC	10752619
Intra	CD247	P20963	ZAP70	Homo sapiens	P43403	CoIP	7509083
Intra	CD247	P20963	ZAP70	Homo sapiens	P43403	Enzymatic Study	8901551
Intra	CD247	P20963	ZAP70	Homo sapiens	P43403	SPR	8648092
Intra	CD247	P20963	ZAP70	Homo sapiens	P43403	Pull Down	7528772
Intra	CD247	P20963	ZAP70	Homo sapiens	P43403	Enzymatic Study	10704231
Intra	CD247	P20963	ZAP70	Homo sapiens	P43403	Peptide Array	15832366
Intra	CD247	P20963	CD247	Homo sapiens	P20963	Anti Bait CoIP	17055436
Intra	CD247	P20963	ZAP70	Homo sapiens	P43403	Pull Down	8648092
Intra	CD247	P20963	PTPN22	Homo sapiens	Q9Y2R2	Pull Down	16461343
Intra	CD247	P20963	NCK1	Homo sapiens	P16333	Pull Down	18320063
Intra	CD247	P20963	SH2D1A	Homo sapiens	O60880	Far-WB	22912825
Intra	CD247	P20963	SH2D1A	Homo sapiens	O60880	Pull Down	22912825
Intra	CD247	P20963	SH2D1A	Homo sapiens	O60880	Anti Bait CoIP	22912825
Intra	CD247	P20963	ARRB1	Homo sapiens	P49407	Pull Down	24502978
Cross	CD247	P20963	Ccr7	Mus musculus	P47774	Anti Bait CoIP	22922463

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD247 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76220	CD3 zeta/CD247 Protein, Human (His)	P20963-1 (R52-R164)	≥ 95%, as determined by reducing SDS-PAGE.

CD247 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82680	Phospho-CD3 zeta (Tyr142) Antibody (YA2425)	WB, IP	Human
HY-P82680A	Phospho-CD3 zeta (Tyr142) Antibody (YA2425)(PBS only)	WB, IP	Human
HY-P84176	CD3 zeta Antibody (YA3873)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84176A	CD3 zeta Antibody (YA3873)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P85086	CD3 zeta Antibody (YA4778)	WB, IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Immunodeficiency 25	Immunodeficiency Due To Defect In Cd3-Zeta IMD25 Immunodeficiency, Type 25
T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta	T-B+ Scid Due To Cd3delta/Cd3epsilon/Cd3zeta
Oligoarticular Juvenile Idiopathic Arthritis	Oligoarticular Jia Pauciarticular Chronic Arthritis Juvenile Pauciarticular Chronic Arthritis
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis	Juvenile Polyarthritis Without Rheumatoid Factor Juvenile Rheumatoid Factor-Negative Polyarthritis Rheumatoid Factor-Negative Polyarticular Jia Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative
Cd3zeta Deficiency
Immunodeficiency 18	IMD18 Cd3-Epsilon Deficiency Immunodeficiency 18, Scid Variant Cd3epsilon Deficiency Immunodeficiency 18, Severe Combined Immunodeficiency Variant Immunodeficiency, Type 18
Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Immunodeficiency 19	IMD19 Cd3-Delta Deficiency Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive Cd3delta Deficiency Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive Immunodeficiency 19, Severe Combined Cd3d Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive T Cell-Negative, B Cell-Positive, Nk Cell-Positive Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive Severe Combined Immunodeficiency Immunodeficiency, Type 19
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Tetanus	Lockjaw Clostridial Tetanus Infection Due To Clostridium Tetani Lock-Jaw
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Inflammatory Bowel Disease 18	IBD18
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Parotid Gland Adenoid Cystic Carcinoma	Adenoid Cystic Carcinoma Of Parotid Gland
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02214	CD247 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21508	Cd247 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28026	Cd247 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CD247	VGNC	VGNC:27016
Rattus norvegicus	CD247	RGD	RGD:2305
Mus musculus	CD247	MGD	MGI:88334
Felis catus	CD247	VGNC	VGNC:60600
Macaca mulatta	CD247	VGNC	VGNC:70765
Others	CD247	NCBI