Cdh4 - cadherin 4 Gene

Also Known as Rcad; R-CAD; R-Cadh

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12561

Summary

This gene encodes a member of the Cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. The encoded protein is involved in retinal angiogenesis during development where it plays a crucial role in the endothelial-astrocyte interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

Cdh4 Products (2)

mRNA Protein Name
NM_001316723.1 NP_001303652.1 cadherin-4 isoform 2 precursor
NM_009867.3 NP_033997.1 cadherin-4 isoform 1 preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of axon extension IDA
IDA: Inferred from direct assay
14586016 MGI
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
14586016 MGI
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: Inferred from direct assay
8270638 MGI
acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: Inferred from direct assay
8270638 MGI
acts upstream of or within positive regulation of axon extension IDA
IDA: Inferred from direct assay
14586016 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
8270638 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cadherin-4

  • R-cadherin

  • retina cadherin

  • retinal cadherin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02337 CDH4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18750 Cdh4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25237 Cdh4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdh4 NCBI NCBI:1002