ADH1C - alcohol dehydrogenase 1C (class I), gamma polypeptide Gene

Also Known as ADH3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 126

About ADH1C

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,336,497-99,352,746 (from NCBI)

This gene has 4 transcripts (splice variants), 363 orthologues, 17 paralogues and is associated with 2 phenotypes. Biased expression in liver (RPKM 388.0), duodenum (RPKM 230.6) and 5 other tissues.

Summary

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, Other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation to acetaldehyde, thus playing a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. An association between ADH1C polymorphism and alcohol dependence has not been established. [provided by RefSeq, Sep 2019]

ADH1C Products (1)

mRNA Protein Name
NM_000669.5 NP_000660.1 alcohol dehydrogenase 1C

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables alcohol dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
6391957 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alcohol dehydrogenase 1C

  • ADH, gamma subunit

ADH1C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ADH1C P00326 ADH1B Homo sapiens P00325
Anti Tag CoIP
33961781
Intra
ADH1C P00326 ADH1B Homo sapiens P00325
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Parkinson Disease, Mitochondrial
Alcoholic Liver Cirrhosis

  • Alcoholic Cirrhosis

  • Portal Cirrhosis

  • Alcoholic Cirrhosis Of Liver

  • Liver Cirrhosis, Alcoholic

  • Laennec'S Cirrhosis

  • Laennec'S Cirrhosis, Alcoholic

  • Alcohol Cirrhosis

  • Alcoholic Laennec Cirrhosis

  • Alcoholic Cirrhosis Nos

  • Etoh Cirrhosis

  • Alcohol Hepatic Cirrhosis

  • Alcohol Liver Cirrhosis

  • Laennec Cirrhosis
Oropharynx Cancer

  • Oropharyngeal Cancer

  • Oropharyngeal Carcinoma

  • Malignant Neoplasm Of Oropharynx

  • Malignant Oropharyngeal Tumor

  • Malignant Tumor Of Oropharynx

  • Malignant Tumour Of Mesopharynx

  • Oropharyngeal Cancer, Adult

  • Cancer Of The Oropharynx
Pharynx Cancer

  • Pharyngeal Cancer

  • Pharyngeal Neoplasms

  • Pharyngeal Neoplasm

  • Pharynx Neoplasm

  • Malignant Neoplasm Of Pharynx

  • Pharyngeal Carcinoma
Alcoholic Pancreatitis

  • Pancreatitis, Alcoholic

  • Pancreatitis Alcoholic
Alcohol Use Disorder

  • Alcohol Abuse

  • Alcoholism

  • Ethanol Abuse

  • Alcohol Addiction

  • Alcohol Dependence

  • Alcoholic Intoxication, Chronic

  • Alcohol-Related Disorders
Liver Cirrhosis

  • Cirrhosis

  • Cirrhosis Of Liver

  • CIRRH

  • Cryptogenic Cirrhosis

  • Cirrhosis, Cryptogenic

  • Cirrhosis Nos
Pancreatitis

  • Mumps Pancreatitis
Aspartylglucosaminuria

  • Aspartylglycosaminuria

  • Glycosylasparaginase Deficiency

  • Aspartylglucosaminidase Deficiency

  • Aga Deficiency

  • AGU

  • Aspartylglucosamidase Deficiency

  • Glycoasparaginase

  • Aspartylglucosamidase Deficiency

  • Hyperammonemia, Type Iii
Alcohol-Related Birth Defects

  • Arbd

  • Alcohol-Related Birth Defect

  • Alcohol Related Birth Defect

  • Fetal Alcohol Syndrome
Substance Dependence
Lip And Oral Cavity Cancer

  • Oral Cancer

  • Lip And Oral Cavity Carcinoma

  • Malignant Neoplasm Of Mouth
Fetal Alcohol Syndrome

  • Fetal Alcohol Spectrum Disorders

  • Arbd

  • Arnd

  • Alcohol-Related Birth Defects

  • Alcohol-Related Neurodevelopmental Disorder

  • Fas

  • Fasd

  • Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk

  • Alcohol Related Birth Defect

  • Alcohol Related Neurodevelopmental Disorder

  • Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk

  • Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk

  • Dysmorphism Due To Alcohol

  • Fetal Etoh Syndrome
Substance Abuse

  • Substance-Related Disorders

  • Substance Abuse Problem
Fetal Alcohol Spectrum Disorder

  • Fetal Alcohol Spectrum Disorders

  • Fetal Alcohol Syndrome
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Squamous Cell Carcinoma, Head And Neck

  • Squamous Cell Carcinoma Of The Head And Neck

  • HNSCC

  • Head And Neck Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Lip

  • Squamous Cell Carcinoma, Head And Neck, Somatic

  • Carcinoma Of The Head And Neck

  • Squamous Cell Carcinomas Of Head And Neck

  • Scchn

  • Squamous Cell Carcinoma Of The Hypopharynx

  • Squamous Cell Carcinoma Of The Oropharynx

  • Squamous Cell Carcinoma Of Salivary Glands

  • Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

  • Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

  • Squamous Cell Carcinoma Of The Oral Cavity

  • Squamous Cell Carcinoma Of The Lip

  • Carcinoma, Squamous Cell Of Head And Neck

  • Lip Squamous Cell Carcinoma

  • Carcinoma, Squamous Cell, Head And Neck

  • Salivary Gland Squamous Cell Carcinoma

  • Cancer Of Head And Neck

  • Squamous Cell Carcinoma Of Oropharynx Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00368 ADH1C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27366 Adh1c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ADH1C RGD RGD:2044
Mus musculus ADH1C MGD MGI:87921