Cflar - CASP8 and FADD-like apoptosis regulator Gene

Also Known as Cash; Flip; MRIT; CLARP; FLAME; Casper; Gm9845; c-Flip; FLAME-1; I-FLICE; 2310024N18Rik; A430105C05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12633

Summary

Enables peptidase activator activity. Involved in several processes, including negative regulation of myoblast fusion; positive regulation of NF-kappaB transcription factor activity; and skeletal muscle atrophy. Acts upstream of or within negative regulation of programmed cell death and response to bacterium. Located in cytoplasm. Is expressed in several structures, including central nervous system; gut; heart; peripheral nervous system ganglion; and retina. Orthologous to human CFLAR (CASP8 and FADD like Apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]

Cflar Products (6)

mRNA Protein Name
NM_001289704.3 NP_001276633.1 CASP8 and FADD-like apoptosis regulator isoform 1
NM_001293804.2 NP_001280733.1 CASP8 and FADD-like apoptosis regulator isoform 4
NM_001293805.2 NP_001280734.1 CASP8 and FADD-like apoptosis regulator isoform 4
NM_001355056.1 NP_001341985.1 CASP8 and FADD-like apoptosis regulator isoform 4
NM_009805.4 NP_033935.2 CASP8 and FADD-like apoptosis regulator isoform 2
NM_207653.6 NP_997536.1 CASP8 and FADD-like apoptosis regulator isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptidase activator activity IDA
IDA: Inferred from direct assay
21368763 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21368763 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
16263940 MGI
acts upstream of necroptotic process IGI
IGI: Inferred from genetic interaction
21368763 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16263940 MGI
acts upstream of or within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
16263940 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
22675671 MGI
involved in negative regulation of myoblast fusion IMP
IMP: Inferred from mutant phenotype
21364645 MGI
acts upstream of or within negative regulation of necroptotic process IGI
IGI: Inferred from genetic interaction
21368763 MGI
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
21364645 MGI
involved in regulation of skeletal muscle satellite cell proliferation IMP
IMP: Inferred from mutant phenotype
21364645 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
involved in skeletal muscle atrophy IMP
IMP: Inferred from mutant phenotype
21364645 MGI
involved in skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
21364645 MGI
involved in skeletal muscle tissue regeneration IMP
IMP: Inferred from mutant phenotype
21364645 MGI
involved in skeletal myofibril assembly IMP
IMP: Inferred from mutant phenotype
21364645 MGI
involved in wound healing IMP
IMP: Inferred from mutant phenotype
21364645 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16263940 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CASP8 and FADD-like apoptosis regulator

  • FADD-like antiapoptotic molecule 1

  • MACH-related inducer of toxicity

  • caspase homolog

  • caspase-eight-related protein

  • caspase-like apoptosis regulatory protein

  • cellular FLICE-like inhibitory protein

  • inhibitor of FLICE

  • usurpin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02570 CFLAR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21525 Cflar Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28043 Cflar Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cflar NCBI NCBI:8837