Ccr4 - chemokine (C-C motif) receptor 4 Gene

Also Known as LESTR; Sdf1r; CHEMR1; Cmkbr4; C-C CKR-4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12773

About Ccr4

Chromosome 9: 114,319,384-114,333,984 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 114 orthologues, 25 paralogues and is associated with 29 phenotypes. Biased expression in thymus adult (RPKM 1.4), testis adult (RPKM 1.5) and 2 other tissues.

Summary

Enables C-C Chemokine Receptor activity. Acts upstream of or within several processes, including homeostasis of number of cells; neuron migration; and tolerance induction. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; intestine; pyloric antrum; reproductive system; and thymus. Orthologous to human CCR4 (C-C motif Chemokine Receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Ccr4 Products (2)

mRNA Protein Name
NM_009916.2 NP_034046.2 C-C chemokine receptor type 4
NM_009916.2 NP_034046.2 C-C chemokine receptor type 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables C-C chemokine receptor activity IMP
IMP: Inferred from mutant phenotype
10811868 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chemotaxis IMP
IMP: Inferred from mutant phenotype
10811868 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
24069263 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
10811868 MGI
acts upstream of or within interneuron migration IMP
IMP: Inferred from mutant phenotype
16262623 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
16262623 MGI
acts upstream of or within tolerance induction IMP
IMP: Inferred from mutant phenotype
15809349 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
19008373 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr4 Protein Structure

7tmA_Chemokine_R

7tmA_Chemokine_R: cd14984 (39 - 66)

7tmA_Chemokine_R

7tmA_Chemokine_R: cd14984 (39 - 314)

7tmA_Chemokine_R

7tmA_Chemokine_R: cd14984 (73 - 98)

7tmA_Chemokine_R

7tmA_Chemokine_R: cd14984 (109 - 139)

7tmA_Chemokine_R

7tmA_Chemokine_R: cd14984 (153 - 173)

7tmA_Chemokine_R

7tmA_Chemokine_R: cd14984 (198 - 227)

7tmA_Chemokine_R

7tmA_Chemokine_R: cd14984 (234 - 264)

7tmA_Chemokine_R

7tmA_Chemokine_R: cd14984 (282 - 307)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
Protein Preferred Names Protein Names

C-C chemokine receptor type 4

  • chemokine (C-C) receptor 4

  • fusin

  • leukocyte-expressed seven-transmembrane-domain receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99253 Mogamulizumab Inhibitor 96.9% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-148074 Zelnecirnon Inhibitor 99.71% Phase 2
HY-148494 Tivumecirnon Antagonist 99.48% Phase 2
HY-100183 GSK2239633A Antagonist 99.81% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-U00064 AZD2098 Inhibitor 99.91% Unkown
HY-103364A C-021 dihydrochloride Antagonist 99.73% Unkown
HY-103364 C-021 Inhibitor 99.95% Unkown
HY-157453 CCR4 antagonist 4 Antagonist 98.92% Unkown
HY-P3418 CKLF1-C27 Inhibitor 98.02% Unkown
HY-P3982 CKLF1-C19 Chemical 99.11% Unkown
HY-131349 CCR4-351 Antagonist 98.95% Unkown
HY-131349A CCR4-351 hydrochloride Antagonist 98.14% Unkown
HY-147385 CCR4 antagonist 3 Antagonist 99.94% Unkown
HY-122565 GSK-2239633 Antagonist / Unkown
HY-P3418A CKLF1-C27 TFA Inhibitor / Unkown
HY-182564 ST45177901 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccr4 NCBI NCBI:1233