Ccr4 - chemokine (C-C motif) receptor 4 Gene

Mus musculus

Also known as LESTR; Sdf1r; CHEMR1; Cmkbr4; C-C CKR-4

Gene ID: 12773 | Gene type: protein coding

About Ccr4

Chromosome 9: 114,319,384-114,333,984 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 114 orthologues, 25 paralogues and is associated with 29 phenotypes. Biased expression in thymus adult (RPKM 1.4), testis adult (RPKM 1.5) and 2 other tissues.

Summary

Enables C-C Chemokine Receptor activity. Acts upstream of or within several processes, including homeostasis of number of cells; neuron migration; and tolerance induction. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; intestine; pyloric antrum; reproductive system; and thymus. Orthologous to human CCR4 (C-C motif Chemokine Receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Ccr4 Products(1)

mRNA	Protein	Name
NM_009916.2	NP_034046.2	C-C chemokine receptor type 4

Ccr4 Protein Structure

7tmA_Chemokine_R

0
100
200
300
360 a.a.

Protein Preferred Names

Protein Names

C-C chemokine receptor type 4

chemokine (C-C) receptor 4	fusin
leukocyte-expressed seven-transmembrane-domain receptor

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99253	Mogamulizumab	Inhibitor	95.00%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-148074	Zelnecirnon	Inhibitor	99.84%	Phase 2

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-U00064	AZD2098	Inhibitor	99.84%	Unkown
HY-103364	C-021	Inhibitor	99.94%	Unkown
HY-119293	K777	Antagonist	99.77%	Unkown
HY-100183	GSK2239633A	Antagonist	99.86%	Unkown
HY-131349	CCR4-351	Antagonist	98.02%	Unkown
HY-103364A	C-021 dihydrochloride	Antagonist	99.92%	Unkown
HY-P3982	CKLF1-C19	Chemical	99.95%	Unkown
HY-157453	CCR4 antagonist 4	Antagonist	99.72%	Unkown
HY-147385	CCR4 antagonist 3	Antagonist	99.94%	Unkown
HY-131349A	CCR4-351 hydrochloride	Antagonist	98.59%	Unkown
HY-P3418	CKLF1-C27	Inhibitor	98.50%	Unkown
HY-P3418A	CKLF1-C27 TFA	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccr4	NCBI	NCBI:1233

Name
Email *

	Sorry, but the email address you supplied was invalid.