Ctsc - cathepsin C Gene

Also Known as CatC; DPP1; DPPI

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13032

About Ctsc

Chromosome 7: 87,927,293-87,960,096 forward strand.GRCm39:CM001000.3

This gene has 5 transcripts (splice variants), 233 orthologues, 24 paralogues and is associated with 14 phenotypes. Ubiquitous expression in lung adult (RPKM 8.), mammary gland adult (RPKM 4.8) and 22 other tissues.

Summary

This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the Dipeptidyl Peptidase 1 light, heavy, and exclusion domain chains, which together comprise one subunit of the homotetrameric enzyme. This enzyme has amino dipeptidase activity and may play a role in the activation of granzymes during inflammation. Homozygous knockout mice for this gene exhibit impaired granzyme activation and enhanced survival in a sepsis model. [provided by RefSeq, Aug 2015]

Ctsc Products (4)

mRNA	Protein	Name
NM_009982.6	NP_034112.3	dipeptidyl peptidase 1 isoform 1 preproprotein
NM_001412310.1	NP_001399239.1	dipeptidyl peptidase 1 isoform 3 preproprotein
NM_001412311.1	NP_001399240.1	dipeptidyl peptidase 1 isoform 4 precursor
NM_001311790.2	NP_001298719.1	dipeptidyl peptidase 1 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type peptidase activity	IDA IDA: Inferred from direct assay	28251676	MGI
enables peptidase activator activity involved in apoptotic process	IGI IGI: Inferred from genetic interaction	20435891	MGI
enables serine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	20435891	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in T cell mediated cytotoxicity	IGI IGI: Inferred from genetic interaction	20435891	MGI
acts upstream of or within negative regulation of myelination	IDA IDA: Inferred from direct assay	28251676	MGI
acts upstream of or within negative regulation of myelination	IMP IMP: Inferred from mutant phenotype	28251676	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	20435891	MGI
acts upstream of or within positive regulation of microglial cell activation	IDA IDA: Inferred from direct assay	28251676	MGI
involved in proteolysis	IMP IMP: Inferred from mutant phenotype	20435891	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	28251676	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctsc Protein Structure

CathepsinC_exc

Pox_I6

Peptidase_C1A_CathepsinC

0
100
200
300
400
462 a.a.

Protein Preferred Names	Protein Names
dipeptidyl peptidase 1	cathepsin J dipeptidyl peptidase I dipeptidyl transferase

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112318A	GSK-2793660	Inhibitor	99.91%	Phase 1
HY-112318	GSK-2793660 free base	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03325	CTSC Human Pre-designed siRNA Set A		/	Unkown
HY-168591	CTSC-IN-1	Inhibitor	/	Unkown
HY-RS03326	Ctsc Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS03327	Ctsc Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctsc	NCBI	NCBI:1075