Ctse - cathepsin E Gene

Also Known as CE; CatE; A430072O03Rik; C920004C08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13034

About Ctse

Chromosome 1: 131,566,044-131,603,243 forward strand.GRCm39:CM000994.3

This gene has 3 transcripts (splice variants), 142 orthologues, 8 paralogues and is associated with 17 phenotypes. Biased expression in stomach adult (RPKM 438.1), bladder adult (RPKM 7.7) and 3 other tissues.

Summary

This gene encodes a member of the peptidase A1 family of aspartate proteases and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. Homozygous knockout mice for this gene exhibit lysosomal storage disorder, impaired Autophagy, mitochondrial abnormalities, dermatitis, and reduced weight gain in an obesity model. [provided by RefSeq, Aug 2015]

Ctse Products (2)

mRNA Protein Name
NM_007799.3 NP_031825.2 cathepsin E preproprotein
NM_007799.3 NP_031825.2 cathepsin E preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aspartic-type endopeptidase activity IDA
IDA: Inferred from direct assay
9180269 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
15100295 MGI
Biological Process GO Annotation Evidence References Source
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
IDA: Inferred from direct assay
11719510 MGI
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
1601038 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctse Protein Structure

A1_Propeptide

A1_Propeptide: pfam07966 (21 - 49)

pepsin_retropepsin_like

pepsin_retropepsin_like: cl11403 (78 - 393)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
Protein Preferred Names Protein Names

cathepsin E

Recombinant Ctse Proteins

Cat. No. Product Name Accession Purity
HY-P7751 Cathepsin E Protein, Mouse (HEK293, His) P70269 (S60-P397) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03331 CTSE Human Pre-designed siRNA Set A / Unkown
HY-RS03332 Ctse Mouse Pre-designed siRNA Set A / Unkown
HY-RS03333 Ctse Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctse NCBI NCBI:1510