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ADH7 - alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Gene

Also Known as ADH4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 131

About ADH7

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,412,263-99,435,342 (from NCBI)

This gene has 6 transcripts (splice variants), 350 orthologues and 17 paralogues. Restricted expression toward esophagus (RPKM 95.5).

Summary

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, Other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the Other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

ADH7 Products (2)

mRNA	Protein	Name
NM_000673.7	NP_000664.3	all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform 2
NM_001166504.2	NP_001159976.1	all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables alcohol dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	7876099	GOA
enables aldehyde oxidase activity	IDA IDA: Inferred from direct assay	9600267	GOA
enables all-trans-retinol dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	7876099	GOA
enables ethanol binding	IDA IDA: Inferred from direct assay	9228021	GOA
enables receptor antagonist activity	IDA IDA: Inferred from direct assay	9600267	GOA
enables retinol binding	IDA IDA: Inferred from direct assay	9228021	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in fatty acid omega-oxidation	IDA IDA: Inferred from direct assay	9600267	GOA
involved in response to bacterium	IDA IDA: Inferred from direct assay	11410738	GOA
involved in response to ethanol	IDA IDA: Inferred from direct assay	9600267	GOA
involved in retinoid metabolic process	IDA IDA: Inferred from direct assay	9600267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADH7 Protein Structure

ADH_N

ADH_zinc_N

0
100
200
300
386 a.a.

Protein Preferred Names	Protein Names
all-trans-retinol dehydrogenase [NAD(+)] ADH7	alcohol dehydrogenase VII

Recombinant ADH7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7473	ADH7 Protein, Human (HEK293, His)	P40394 (M1-F386)	≥ 80%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Atrophic Gastritis	Gastritis, Atrophic Gastric Atrophy Gastritis Atrophic
Gastritis	Acute Gastric Mucosal Erosion Erosive Gastritis Erosive Gastropathy Gastritis Erosive Idiopathic Erosive/Hemorrhagic Gastritis Inflammation Of Gastric Mucosa Gastroduodenitis Gastritis Nos Noninfectious Gastroenteritis Nonbacterial Gastroenteritis Of Infant Acute Gastric Infection Acute Simple Gastritis Chronic Antral Gastritis Chronic Fundal Gastritis Chronic Simple Gastritis Acute Gastroduodenitis Acute Antral Gastritis Acute Erosive Gastritis Bile Reflux Gastritis Gastritis Due To Biliary Reflux
Fetal Alcohol Syndrome	Fetal Alcohol Spectrum Disorders Arbd Arnd Alcohol-Related Birth Defects Alcohol-Related Neurodevelopmental Disorder Fas Fasd Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk Alcohol Related Birth Defect Alcohol Related Neurodevelopmental Disorder Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk Dysmorphism Due To Alcohol Fetal Etoh Syndrome
Alcoholic Cardiomyopathy	Cardiomyopathy, Alcoholic Alcohol-Induced Heart Muscle Disease Dilated Cardiomyopathy Secondary To Alcohol
Substance Dependence
Fetal Alcohol Spectrum Disorder	Fetal Alcohol Spectrum Disorders Fetal Alcohol Syndrome
Alcohol Use Disorder	Alcohol Abuse Alcoholism Ethanol Abuse Alcohol Addiction Alcohol Dependence Alcoholic Intoxication, Chronic Alcohol-Related Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00374	ADH7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19572	Adh7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26069	Adh7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADH7	RGD	RGD:621638
Mus musculus	ADH7	MGD	MGI:87926