ADH7 - alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Gene

Homo sapiens

Also known as ADH4

Gene ID: 131 | Gene type: protein coding

About ADH7

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,412,263-99,435,342 (from NCBI)

This gene has 6 transcripts (splice variants), 350 orthologues and 17 paralogues. Restricted expression toward esophagus (RPKM 95.5).

Summary

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The Enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

ADH7 Products(2)

mRNA	Protein	Name
NM_000673.7	NP_000664.3	all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform 2
NM_001166504.2	NP_001159976.1	all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform 1

ADH7 Protein Structure

ADH_N

ADH_zinc_N

0
100
200
300
386 a.a.

Protein Preferred Names

Protein Names

all-trans-retinol dehydrogenase [NAD(+)] ADH7

alcohol dehydrogenase VII

Recombinant ADH7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7473	ADH7 Protein, Human (HEK293, His)	P40394 (M1-F386)	≥95%

Related Diseases

Diseases

Alias

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Atrophic Gastritis

Gastritis, Atrophic	Gastric Atrophy
Gastritis Atrophic

Gastritis

Acute Gastric Mucosal Erosion	Erosive Gastritis
Erosive Gastropathy	Gastritis Erosive
Idiopathic Erosive/Hemorrhagic Gastritis	Inflammation Of Gastric Mucosa
Gastroduodenitis	Gastritis Nos
Noninfectious Gastroenteritis	Nonbacterial Gastroenteritis Of Infant
Acute Gastric Infection	Acute Simple Gastritis
Chronic Antral Gastritis	Chronic Fundal Gastritis
Chronic Simple Gastritis	Acute Gastroduodenitis
Acute Antral Gastritis	Acute Erosive Gastritis
Bile Reflux Gastritis	Gastritis Due To Biliary Reflux

Fetal Alcohol Syndrome

Fetal Alcohol Spectrum Disorders	Arbd
Arnd	Alcohol-Related Birth Defects
Alcohol-Related Neurodevelopmental Disorder	Fas
Fasd	Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk
Alcohol Related Birth Defect	Alcohol Related Neurodevelopmental Disorder
Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk	Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk
Dysmorphism Due To Alcohol	Fetal Etoh Syndrome

Alcoholic Cardiomyopathy

Cardiomyopathy, Alcoholic	Alcohol-Induced Heart Muscle Disease
Dilated Cardiomyopathy Secondary To Alcohol

Substance Dependence

Fetal Alcohol Spectrum Disorder

Fetal Alcohol Spectrum Disorders