Ddc - dopa decarboxylase Gene

Also Known as Aadc

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13195

Summary

Enables aromatic-L-amino-acid decarboxylase activity. Acts upstream of or within response to toxic substance. Located in cytoplasm. Is expressed in several structures, including alimentary system; heart; nervous system; respiratory system; and sensory organ. Used to study aromatic L-amino acid decarboxylase deficiency. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and inherited metabolic disorder. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]

Ddc Products (2)

mRNA Protein Name
NM_001190448.1 NP_001177377.1 aromatic-L-amino-acid decarboxylase
NM_016672.4 NP_057881.1 aromatic-L-amino-acid decarboxylase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aromatic-L-amino-acid decarboxylase activity IDA
IDA: Inferred from direct assay
23863468 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
22169008 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
22688335 MGI
acts upstream of or within response to toxic substance IDA
IDA: Inferred from direct assay
7904615 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23010799 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aromatic-L-amino-acid decarboxylase

Recombinant Ddc Proteins

Cat. No. Product Name Accession Purity
HY-P74204 DDC Protein, Mouse (sf9, His) O88533 (M1-E480) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17392 Zalcitabine Inhibitor 99.81% Yes

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-118594 Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate Inhibitor 99.83% Unkown
HY-139997 DDC-01-163 Degrader 99.05% Unkown
HY-151048 JBJ-07-149 Inhibitor 99.09% Unkown
HY-156179 DDC 2′,3′-O-disulfate Inhibitor / Unkown
HY-156180 DDC 3′-O-β-D glucuronide / Unkown
HY-163203 DDC18-8A Inhibitor / Unkown
HY-163461 4F-DDC Inhibitor / Unkown
HY-170351 NH2-PEG2-OMs / Unkown
HY-RS03608 DDC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-170350 Pomalidomide-PEG2-OMs / Unkown
HY-180325 DDC4002 Inhibitor / Unkown
HY-RS16935 Ddc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23378 Ddc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W393396 3'-NH2-ddC / Unkown
HY-W784611 3'-NH-Tr-2',3'-ddC(Bz)-5'-CE-Phosphoramidite / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddc NCBI NCBI:1644