Dffa - DNA fragmentation factor, alpha subunit Gene

Also Known as ICAD; DFF35; Dff45; ICAD-L; ICAD-S; A330085O09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13347

Summary

Predicted to enable deoxyribonuclease inhibitor activity; protein domain specific binding activity; and protein folding chaperone. Acts upstream of or within negative regulation of apoptotic DNA fragmentation; positive regulation of apoptotic process; and thymocyte apoptotic process. Predicted to be located in several cellular components, including chromatin; cytosol; and nucleus. Predicted to be part of protein-containing complex. Is expressed in several structures, including brain; heart; hemolymphoid system gland; liver; and metanephros. Orthologous to human DFFA (DNA fragmentation factor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Dffa Products (2)

mRNA Protein Name
NM_001025296.2 NP_001020467.1 DNA fragmentation factor subunit alpha isoform a
NM_010044.3 NP_034174.2 DNA fragmentation factor subunit alpha isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14557248 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of apoptotic DNA fragmentation IMP
IMP: Inferred from mutant phenotype
10601318 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
14663139 MGI
acts upstream of or within thymocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
10601318 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA fragmentation factor subunit alpha

  • DNA fragmentation factor 45 kDa subunit

  • inhibitor of CAD

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03708 DFFA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18032 Dffa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24506 Dffa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dffa NCBI NCBI:1676