COX7A2 - cytochrome c oxidase subunit 7A2 Gene

Homo sapiens

Also known as VIIAL; COX7AL; COX7AL1; COXVIIAL; COXVIIa-L

Gene ID: 1347 | Gene type: protein coding

About COX7A2

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:75,237,675-75,250,298 (from NCBI)

This gene has 9 transcripts (splice variants), 304 orthologues and 2 paralogues. Broad expression in testis (RPKM 131.2), colon (RPKM 111.8) and 25 other tissues.

Summary

Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009]

COX7A2 Products(3)

mRNA	Protein	Name
NM_001366292.3	NP_001353221.2	cytochrome c oxidase subunit 7A2, mitochondrial
NM_001366293.2	NP_001353222.1	cytochrome c oxidase subunit 7A2, mitochondrial
NM_001865.6	NP_001856.3	cytochrome c oxidase subunit 7A2, mitochondrial

COX7A2 Protein Structure

COX7a

0
83 a.a.

Protein Preferred Names

Protein Names

cytochrome c oxidase subunit 7A2, mitochondrial

cytochrome c oxidase polypeptide 7A2, mitochondrial

Related Diseases

Diseases

Alias

Barrett'S Adenocarcinoma

Barrett Adenocarcinoma

Adenocarcinoma Arising In Barrett'S Mucosa

Neurodegeneration With Brain Iron Accumulation 4

NBIA4	Mpan
Mitochondrial Protein-Associated Neurodegeneration	Nbia Due To C19orf12 Mutation
Neurodegeneration With Brain Iron Accumulation Due To C19orf12 Mutation	Neurodegeneration With Brain Iron Accumulation Type 4
Mitochondrial Membrane Protein Associated Neurodegeneration	Neurodegeneration, With Brain Iron Accumulation, Type 4

Esophagus Adenocarcinoma

Esophageal Adenocarcinoma	Oesophageal Adenocarcinoma
Adenocarcinoma Of Esophagus	Adenocarcinoma Of The Esophagus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03074	COX7A2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS03075	COX7A2L Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	COX7A2	MGD	MGI:1316715
Felis catus	COX7A2	VGNC	VGNC:102408
Rattus norvegicus	COX7A2	RGD	RGD:68365
Bos taurus	COX7A2	VGNC	VGNC:53788

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