COX7A2 - cytochrome c oxidase subunit 7A2 Gene

Also Known as VIIAL; COX7AL; COX7AL1; COXVIIAL; COXVIIa-L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1347

About COX7A2

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:75,237,675-75,250,298 (from NCBI)

This gene has 9 transcripts (splice variants), 304 orthologues and 2 paralogues. Broad expression in testis (RPKM 131.2), colon (RPKM 111.8) and 25 other tissues.

Summary

Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009]

COX7A2 Products (3)

mRNA Protein Name
NM_001366292.3 NP_001353221.2 cytochrome c oxidase subunit 7A2, mitochondrial
NM_001366293.2 NP_001353222.1 cytochrome c oxidase subunit 7A2, mitochondrial
NM_001865.6 NP_001856.3 cytochrome c oxidase subunit 7A2, mitochondrial

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
30030519 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COX7A2 Protein Structure

COX7a

COX7a: Cytochrome c oxidase subunit VII (25 - 81)

  • 0
  • 83 a.a.
Protein Preferred Names Protein Names

cytochrome c oxidase subunit 7A2, mitochondrial

  • cytochrome c oxidase polypeptide 7A2, mitochondrial

COX7A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
COX7A2 P14406 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
COX7A2 P14406 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
COX7A2 P14406 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Barrett'S Adenocarcinoma

  • Barrett Adenocarcinoma

  • Adenocarcinoma Arising In Barrett'S Mucosa
Neurodegeneration With Brain Iron Accumulation 4

  • NBIA4

  • Mpan

  • Mitochondrial Protein-Associated Neurodegeneration

  • Nbia Due To C19orf12 Mutation

  • Neurodegeneration With Brain Iron Accumulation Due To C19orf12 Mutation

  • Neurodegeneration With Brain Iron Accumulation Type 4

  • Mitochondrial Membrane Protein Associated Neurodegeneration

  • Neurodegeneration, With Brain Iron Accumulation, Type 4
Esophagus Adenocarcinoma

  • Esophageal Adenocarcinoma

  • Oesophageal Adenocarcinoma

  • Adenocarcinoma Of Esophagus

  • Adenocarcinoma Of The Esophagus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03074 COX7A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03075 COX7A2L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21112 Cox7a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27631 Cox7a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus COX7A2 MGD MGI:1316715
Felis catus COX7A2 VGNC VGNC:102408
Rattus norvegicus COX7A2 RGD RGD:68365
Bos taurus COX7A2 VGNC VGNC:53788
Others COX7A2 NCBI