Dpp6 - dipeptidylpeptidase 6 Gene

Also Known as Rw; Dpp-6; Peplb; D5Buc3; D5Buc4; D5Buc5; DPP VI; Gm1377; In(5)6H-p; B930011P16Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13483

Summary

Enables Potassium Channel regulator activity. Involved in protein localization to plasma membrane and regulation of potassium ion transmembrane transport. Acts upstream of or within neuronal action potential and positive regulation of potassium ion transmembrane transport. Located in plasma membrane. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; intervertebral disc; and nose. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; autosomal dominant non-syndromic intellectual disability 33; and spinal muscular atrophy. Orthologous to human DPP6 (Dipeptidyl Peptidase like 6). [provided by Alliance of Genome Resources, Apr 2022]

Dpp6 Products (4)

mRNA	Protein	Name
NM_001136060.2	NP_001129532.1	dipeptidyl aminopeptidase-like protein 6 isoform 1
NM_001198886.1	NP_001185815.1	dipeptidyl aminopeptidase-like protein 6 isoform 4
NM_010075.2	NP_034205.1	dipeptidyl aminopeptidase-like protein 6 isoform 2
NM_207282.3	NP_997165.2	dipeptidyl aminopeptidase-like protein 6 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	22311982	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	24225951	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	21943606	MGI
acts upstream of or within neuronal action potential	IMP IMP: Inferred from mutant phenotype	20573902	MGI
acts upstream of or within positive regulation of potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	21943606	MGI
acts upstream of potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	21943606	MGI
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	22311982	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	20573902	MGI
involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	21943606	MGI
involved in regulation of postsynaptic membrane potential	IEP IEP: Inferred from expression pattern	21943606	MGI
involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	21943606	MGI
involved in regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	22311982	MGI
acts upstream of or within regulation of potassium ion transmembrane transport	IGI IGI: Inferred from genetic interaction	24225951	MGI
acts upstream of or within regulation of potassium ion transport	IMP IMP: Inferred from mutant phenotype	20573902	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	24225951	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	22311982	MGI
is active in synapse	IDA IDA: Inferred from direct assay	23912628	MGI
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	19713751	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
dipeptidyl aminopeptidase-like protein 6	DPPX dipeptidyl aminopeptidase-related protein dipeptidyl peptidase IV-like protein dipeptidyl peptidase VI dipeptidylpeptidase VI inversion, Chr 5, Harwell 6, proximal

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03966	DPP6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21327	Dpp6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27846	Dpp6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dpp6	NCBI	NCBI:1804