S1pr3 - sphingosine-1-phosphate receptor 3 Gene

Also Known as Edg3; Lpb3; S1p3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13610

About S1pr3

Chromosome 13: 51,562,675-51,576,833 forward strand.GRCm39:CM001006.3

This gene has 1 transcript (splice variant), 194 orthologues, 18 paralogues and is associated with 19 phenotypes. Broad expression in limb E14.5 (RPKM 3.), lung adult (RPKM 2.8) and 19 other tissues.

Summary

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. The gene product mediates HDL and HDL-associated lysophospholipid-induced vasorelaxation, and it coordinates with Other lysophospholipid receptors in the process of angiogenesis. [provided by RefSeq, Jan 2010]

S1pr3 Products (1)

mRNA Protein Name
NM_010101.4 NP_034231.1 sphingosine 1-phosphate receptor 3

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
23117660 MGI
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11443127 MGI
acts upstream of or within cytokine production IMP
IMP: Inferred from mutant phenotype
18305483 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
18305483 MGI
acts upstream of or within regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
18305483 MGI
Cellular Component GO Annotation Evidence References Source
is active in presynapse IDA
IDA: Inferred from direct assay
35781853 MGI
is active in presynapse IEP
IEP: Inferred from expression pattern
35781853 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1pr3 Protein Structure

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (42 - 67)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (42 - 308)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (74 - 99)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (111 - 141)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (152 - 172)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (192 - 221)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (235 - 265)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (276 - 301)

  • 0
  • 100
  • 200
  • 300
  • 378 a.a.
Protein Preferred Names Protein Names

sphingosine 1-phosphate receptor 3

  • S1P receptor Edg-3

  • S1p receptor 3

  • endothelial differentiation G-protein coupled receptor 3

  • endothelial differentiation sphingolipid G-protein-coupled receptor 3

  • lysophospholipid receptor B3

  • sphingosine 1-phosphate receptor Edg-3

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12355 Siponimod Agonist 99.95% Yes
HY-10569 Ponesimod Agonist 99.78% Yes
HY-12355A Siponimod hemifumarate Agonist 99.64% Yes

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119401 CAY10444 Antagonist 98.0% Unkown
HY-111253 CYM-5478 Agonist 99.90% Unkown
HY-176533 S1PR5-IN-1 Inhibitor 99.58% Unkown
HY-NP203 High density lipoprotein (human) Activator 98.00% Unkown
HY-113934 L-threo Lysosphingomyelin (d18:1) Agonist 98.0% Unkown
HY-108492 TC-SP 14 Agonist / Unkown
HY-14402 AMG 369 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens S1pr3 NCBI NCBI:1903