CRABP2 - cellular retinoic acid binding protein 2 Gene

Also Known as RBP6; CRABP-II

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1382

About CRABP2

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,699,606-156,705,784 (from NCBI)

This gene has 4 transcripts (splice variants), 267 orthologues and 15 paralogues. Biased expression in esophagus (RPKM 46.7), skin (RPKM 7.1) and 2 other tissues.

Summary

This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein Cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]

CRABP2 Products (2)

mRNA	Protein	Name
NM_001199723.2	NP_001186652.1	cellular retinoic acid-binding protein 2
NM_001878.4	NP_001869.1	cellular retinoic acid-binding protein 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cyclin binding	IDA IDA: Inferred from direct assay	12482873	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15866176	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15866176	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cellular retinoic acid-binding protein 2	cellular retinoic acid-binding protein II

CRABP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CRABP2	P29373	FLAD1	Homo sapiens	Q8NFF5-2	Y2H Array	32296183
Intra	CRABP2	P29373	FLAD1	Homo sapiens	Q8NFF5-2	Y2H Prey Pooling	32296183
Intra	CRABP2	P29373	FLAD1	Homo sapiens	Q8NFF5-2	Validated Y2H	32296183
Intra	CRABP2	P29373	CCND3	Homo sapiens	P30281	Validated Y2H	32296183
Intra	CRABP2	P29373	CCND3	Homo sapiens	P30281	Y2H Array	32296183
Intra	CRABP2	P29373	CCND3	Homo sapiens	P30281	Y2H Prey Pooling	32296183
Intra	CRABP2	P29373	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	CRABP2	P29373	KASH5	Homo sapiens	Q8N6L0	Y2H Array	25416956
Intra	CRABP2	P29373	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	CRABP2	P29373	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CRABP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75688	CRABP2 Protein, Human (His)	P29373 (P2-E138)	≥ 95%, as determined by reducing SDS-PAGE.

CRABP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81907	CRABP2 Antibody (YA1652)	WB, ICC/IF	Human
HY-P81907A	CRABP2 Antibody (YA1652)(PBS only)	WB, ICC/IF	Human

Related Diseases

Diseases	Alias
Embryonal Carcinoma	Embryonal Neoplasm Embryonal Cancer Primary Extragonadal Embryonal Carcinoma Embryo Neoplasm Carcinoma Embryonal Cancer Embryonal Carcinoma, Embryonal Extragonadal Embryonal Carcinoma Cancer, Embryonal
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Hyperlipidemia, Familial Combined, 3	Familial Combined Hyperlipidemia Combined Hyperlipidemia, Familial Mixed Hyperlipidaemia FCHL3 Hyperlipidemia, Familial Combined Familial Multiple Lipoprotein-Type Hyperlipidemia Hyperbetalipoproteinemia With Prebetalipoproteinemia Type Iib Hyperlipoproteinemia Hyperlipidemia Familial Combined Hyperlipoproteinemia Type Iib Mixed Hyperlipemia Hyperlipidaemia, Group C Familial Hypercholesterolaemia With Hyperlipaemia Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia Hyperbetalipoproteinaemia With Prebetalipoproteinaemia Hypercholesterolaemia With Endogenous Hyperglyceridaemia Prebetalipoproteinemia Hyperbetalipoproteinaemia Remnant Hyperlipoproteinemia
Keratoacanthoma	Ka - [Keratoacanthoma] Well-Differentiated Squamous Cell Carcinoma
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Hypervitaminosis A	Hypervitaminosis A, Susceptibility To Hyperalimentation Of Vitamin A
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03135	CRABP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20149	Crabp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26653	Crabp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CRABP2	MGD	MGI:88491
Canis familiaris	CRABP2	VGNC	VGNC:39588
Rattus norvegicus	CRABP2	RGD	RGD:62070
Felis catus	CRABP2	VGNC	VGNC:61156
Bos taurus	CRABP2	VGNC	VGNC:27686
Macaca mulatta	CRABP2	VGNC	VGNC:71481
Others	CRABP2	NCBI