Trpc5 - transient receptor potential cation channel, subfamily C, member 5 Gene

Also Known as Trrp5

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 140933

Summary

Enables ATPase binding activity; clathrin binding activity; and cytoskeletal protein binding activity. Involved in several processes, including generation of neurons; positive regulation of peptidyl-threonine phosphorylation; and regulation of membrane hyperpolarization. Located in several cellular components, including growth cone; membrane raft; and neuronal cell body. Orthologous to human TRPC5 (transient receptor potential cation channel subfamily C member 5). [provided by Alliance of Genome Resources, Apr 2022]

Trpc5 Products (1)

mRNA	Protein	Name
NM_080898.3	NP_543174.1	short transient receptor potential channel 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	16025302	RGD
enables actin binding	IDA IDA: Inferred from direct assay	16025302	RGD
enables actinin binding	IDA IDA: Inferred from direct assay	16025302	RGD
enables clathrin binding	IDA IDA: Inferred from direct assay	16025302	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12857742	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	22764246	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	21618530	RGD
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	21984481	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21984481	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	22764246	RGD
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	20479868	RGD
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	22699894	RGD
involved in regulation of membrane hyperpolarization	IMP IMP: Inferred from mutant phenotype	21179559	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in dendrite	IDA IDA: Inferred from direct assay	22764246	RGD
located in growth cone	IDA IDA: Inferred from direct assay	12858178	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	22764246	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
short transient receptor potential channel 5	transient receptor protein 5

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17386	Rosiglitazone	Modulator	99.94%	Yes
HY-17386A	Rosiglitazone hydrochloride	Modulator	99.81%	Yes
HY-30234A	Clemizole hydrochloride	Inhibitor	99.99%	Yes
HY-30234	Clemizole	Inhibitor	98.42%	Yes
HY-17386B	Rosiglitazone potassium	Modulator	99.13%	Yes

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-162584	TRPC5-IN-6	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133168	Englerin A	Activator	99.50%	Unkown
HY-12949	ML204	Inhibitor	98.45%	Unkown
HY-12949A	ML204 hydrochloride	Inhibitor	99.74%	Unkown
HY-30234S	Clemizole-d4	Inhibitor	99.82%	Unkown
HY-N2595	Oxoglaucine	Inhibitor	/	Unkown
HY-184164	JD03-02	Antagonist	/	Unkown
HY-173024	TRPC4/5-IN-3	Inhibitor	99.65%	Unkown
HY-146155	TRPC4/5-IN-1	Inhibitor	/	Unkown
HY-144429	TRPC5-IN-4	Inhibitor	/	Unkown
HY-162090	TRPC antagonist 1	Antagonist	/	Unkown
HY-172106	TRPC5-IN-5	Inhibitor	/	Unkown
HY-18101	BD-1063	Inhibitor	/	Unkown
HY-30234B	Clemizole sulfate	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trpc5	NCBI	NCBI:7224