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Fgfr3 - fibroblast growth factor receptor 3 Gene

Also Known as FR3; Mfr3; sam3; CD333; Flg-2; HBGFR; Fgfr-3

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14184

About Fgfr3

Chromosome 5: 33,879,018-33,894,412 forward strand.GRCm39:CM000998.3

This gene has 17 transcripts (splice variants), 191 orthologues, 53 paralogues and is associated with 200 phenotypes. Broad expression in lung adult (RPKM 46.), limb E14.5 (RPKM 23.9) and 21 other tissues.

Summary

This gene encodes a member of the Fibroblast Growth Factor receptor family. Members of this family are highly conserved proteins that differ from one another in their ligand affinities and tissue distribution. A representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene may be associated with craniosynostosis and multiple types of skeletal dysplasia. A pseudogene of this gene is located on chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]

Fgfr3 Products (7)

mRNA	Protein	Name
NM_001359036.1	NP_001345965.1	fibroblast growth factor receptor 3 isoform 4 precursor
NM_008010.5	NP_032036.2	fibroblast growth factor receptor 3 isoform 1 precursor
NM_001205270.1	NP_001192199.1	fibroblast growth factor receptor 3 isoform 4 precursor
NM_001163215.2	NP_001156687.1	fibroblast growth factor receptor 3 isoform 1 precursor
NM_001163217.2	NP_001156689.1	fibroblast growth factor receptor 3 isoform 3 precursor
NM_001163216.2	NP_001156688.1	fibroblast growth factor receptor 3 isoform 2 precursor
NM_001359037.1	NP_001345966.1	fibroblast growth factor receptor 3 isoform 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables fibroblast growth factor receptor activity	IDA IDA: Inferred from direct assay	14699054	MGI
enables miRNA binding	IDA IDA: Inferred from direct assay	32060985	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11827956	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	20053668	MGI
acts upstream of MAPK cascade	IMP IMP: Inferred from mutant phenotype	11290300	MGI
acts upstream of or within alveolar secondary septum development	IGI IGI: Inferred from genetic interaction	9716527	MGI
acts upstream of astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	12574417	MGI
acts upstream of or within axonogenesis involved in innervation	IMP IMP: Inferred from mutant phenotype	17557302	MGI
acts upstream of or within bone development	IMP IMP: Inferred from mutant phenotype	20053668	MGI
involved in bone maturation	IMP IMP: Inferred from mutant phenotype	20582225	MGI
involved in bone mineralization	IMP IMP: Inferred from mutant phenotype	20582225	MGI
acts upstream of or within bone morphogenesis	IMP IMP: Inferred from mutant phenotype	19407216	MGI
involved in bone morphogenesis	IMP IMP: Inferred from mutant phenotype	20582225	MGI
acts upstream of or within bone trabecula morphogenesis	IMP IMP: Inferred from mutant phenotype	20053668	MGI
involved in calcium ion homeostasis	IGI IGI: Inferred from genetic interaction	23523568	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	15781473	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	18455718	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15708559	MGI
acts upstream of or within central nervous system myelination	IMP IMP: Inferred from mutant phenotype	12574417	MGI
acts upstream of or within cochlea development	IMP IMP: Inferred from mutant phenotype	17557302	MGI
acts upstream of or within digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	19407216	MGI
acts upstream of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16291864	MGI
acts upstream of or within epithelial cell fate commitment	IMP IMP: Inferred from mutant phenotype	19407216	MGI
acts upstream of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	18455718	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	11290300	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	14699054	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	15781473	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	15708559	MGI
acts upstream of or within inner ear auditory receptor cell differentiation	IGI IGI: Inferred from genetic interaction	17555714	MGI
acts upstream of inner ear auditory receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	17117437	MGI
acts upstream of or within inner ear auditory receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	17117437	MGI
acts upstream of or within inner ear development	IMP IMP: Inferred from mutant phenotype	17117437	MGI
acts upstream of or within lens fiber cell development	IGI IGI: Inferred from genetic interaction	18455718	MGI
acts upstream of or within lens morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	11290300	MGI
acts upstream of mitotic nuclear division	IGI IGI: Inferred from genetic interaction	18455718	MGI
acts upstream of or within morphogenesis of an epithelium	IMP IMP: Inferred from mutant phenotype	17117437	MGI
acts upstream of or within negative regulation of astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	12574417	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15708559	MGI
involved in negative regulation of developmental growth	IMP IMP: Inferred from mutant phenotype	20582225	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	18455718	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	11290300	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20053668	MGI
acts upstream of or within negative regulation of inner ear auditory receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	17117437	MGI
acts upstream of or within negative regulation of mitotic nuclear division	IGI IGI: Inferred from genetic interaction	18455718	MGI
acts upstream of or within negative regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15708559	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	9811582	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9811582	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15708559	MGI
acts upstream of or within neuroepithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	12417662	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15708559	MGI
acts upstream of or within oligodendrocyte development	IMP IMP: Inferred from mutant phenotype	12574417	MGI
acts upstream of or within p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	20053668	MGI
acts upstream of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	14699054	MGI
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	14699054	MGI
acts upstream of or within positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	11290300	MGI
acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	18187602	MGI
acts upstream of or within positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	20053668	MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19407216	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	18187602	MGI
acts upstream of or within positive regulation of cell proliferation in bone marrow	IMP IMP: Inferred from mutant phenotype	20053668	MGI
acts upstream of or within positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16291864	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15708559	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	14699054	MGI
acts upstream of or within positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	14699054	MGI
involved in post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	20582225	MGI
acts upstream of protein ubiquitination	IDA IDA: Inferred from direct assay	14699054	MGI
acts upstream of or within regulation of bone remodeling	IMP IMP: Inferred from mutant phenotype	20053668	MGI
acts upstream of or within regulation of collagen metabolic process	IMP IMP: Inferred from mutant phenotype	20053668	MGI
acts upstream of or within regulation of ossification	IMP IMP: Inferred from mutant phenotype	20053668	MGI
acts upstream of or within regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	20053668	MGI
acts upstream of or within response to axon injury	IMP IMP: Inferred from mutant phenotype	16009496	MGI
involved in response to sodium phosphate	IDA IDA: Inferred from direct assay	23523568	MGI
involved in response to sodium phosphate	IGI IGI: Inferred from genetic interaction	23523568	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	19407216	MGI
acts upstream of or within substantia nigra development	IMP IMP: Inferred from mutant phenotype	17234579	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	14699054	MGI
located in lysosome	IDA IDA: Inferred from direct assay	14699054	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14699054	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fgfr3 Protein Structure

Ig_3

IgI_2_FGFR

PTKc_FGFR3

0
200
400
600
800 a.a.

Protein Preferred Names	Protein Names
fibroblast growth factor receptor 3	heparin-binding growth factor receptor

Recombinant Fgfr3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73056	FGFR-3 alpha (IIIc) Protein, Mouse (HEK293, His-Fc)	Q7TSI8/NP_032036.2 (E21-Y367)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P74153	FGFR-3 alpha (IIIc) Protein, Mouse (HEK293, His)	Q7TSI8/NP_032036.2 (E21-Y367)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77662	FGFR-3 alpha (IIIb) Protein, Mouse (HEK293, His)	E9QNJ9 (P22-V349)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-174981	LC-MF-4	Degrader	98.05%	Unkown
HY-184598	CYB-5067	Degrader	/	Unkown
HY-181752	FGFR3-IN-12	Inhibitor	/	Unkown
HY-183780	FGFR-IN-27	Inhibitor	/	Unkown
HY-160013	FGFR-IN-12	Inhibitor	/	Unkown
HY-184250	FGFR-IN-28	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991106	IMC-D11	Inhibitor	98.51%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgfr3	NCBI	NCBI:2261