Foxc2 - forkhead box C2 Gene

Also Known as Mfh1; Fkh14; MFH-1; Hfhbf3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14234

Summary

Enables several functions, including DNA-binding transcription activator activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of vascular wound healing; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and vasculature development. Predicted to be located in nuclear body. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; limb long bone; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including lymphedema; lymphedema-distichiasis syndrome; obesity; ptosis; and type 2 diabetes mellitus. Orthologous to human FOXC2 (forkhead box C2). [provided by Alliance of Genome Resources, Apr 2022]

Foxc2 Products (1)

mRNA Protein Name
NM_013519.2 NP_038547.2 forkhead box protein C2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
8325367 MGI
enables DNA-binding transcription activator activity IDA
IDA: Inferred from direct assay
9169153 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
18579532 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
18187037 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IGI
IGI: Inferred from genetic interaction
16678147 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
18187037 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
18579532 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IGI
IGI: Inferred from genetic interaction
11562355 MGI
acts upstream of apoptotic process involved in outflow tract morphogenesis IGI
IGI: Inferred from genetic interaction
16839542 MGI
acts upstream of or within artery morphogenesis IMP
IMP: Inferred from mutant phenotype
9409679 MGI
acts upstream of or within blood vessel development IGI
IGI: Inferred from genetic interaction
16678147 MGI
acts upstream of or within blood vessel diameter maintenance IGI
IGI: Inferred from genetic interaction
16678147 MGI
acts upstream of or within blood vessel remodeling IGI
IGI: Inferred from genetic interaction
11562355 MGI
acts upstream of or within branching involved in blood vessel morphogenesis IGI
IGI: Inferred from genetic interaction
15664398 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
10767326 MGI
acts upstream of or within cardiac muscle cell proliferation IGI
IGI: Inferred from genetic interaction
16839542 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
9106663 MGI
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
10767326 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: Inferred from mutant phenotype
9106663 MGI
acts upstream of or within embryonic heart tube development IGI
IGI: Inferred from genetic interaction
16678147 MGI
acts upstream of or within embryonic skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
9409679 MGI
acts upstream of or within embryonic viscerocranium morphogenesis IMP
IMP: Inferred from mutant phenotype
9409679 MGI
acts upstream of or within glomerular endothelium development IMP
IMP: Inferred from mutant phenotype
16498405 MGI
acts upstream of or within glomerular mesangial cell development IMP
IMP: Inferred from mutant phenotype
16498405 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
15664398 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
10479458 MGI
acts upstream of or within heart morphogenesis IGI
IGI: Inferred from genetic interaction
16839542 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
10704385 MGI
acts upstream of or within lymph vessel development IGI
IGI: Inferred from genetic interaction
16678147 MGI
acts upstream of or within metanephros development IMP
IMP: Inferred from mutant phenotype
16498405 MGI
acts upstream of or within negative regulation of apoptotic process involved in outflow tract morphogenesis IGI
IGI: Inferred from genetic interaction
16839542 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18579532 MGI
acts upstream of or within neural crest cell development IGI
IGI: Inferred from genetic interaction
16839542 MGI
acts upstream of or within ossification IMP
IMP: Inferred from mutant phenotype
9106663 MGI
acts upstream of or within paraxial mesoderm formation IGI
IGI: Inferred from genetic interaction
11562355 MGI
acts upstream of or within paraxial mesodermal cell fate commitment IMP
IMP: Inferred from mutant phenotype
9106663 MGI
acts upstream of or within podocyte differentiation IMP
IMP: Inferred from mutant phenotype
16498405 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9169153 MGI
involved in positive regulation of cell adhesion mediated by integrin IDA
IDA: Inferred from direct assay
18579532 MGI
involved in positive regulation of cell migration involved in sprouting angiogenesis IDA
IDA: Inferred from direct assay
18579532 MGI
involved in positive regulation of endothelial cell migration IDA
IDA: Inferred from direct assay
18579532 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16678147 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18579532 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18187037 MGI
involved in positive regulation of vascular wound healing IDA
IDA: Inferred from direct assay
18579532 MGI
acts upstream of or within regulation of organ growth IGI
IGI: Inferred from genetic interaction
16839542 MGI
acts upstream of or within skeletal system development IGI
IGI: Inferred from genetic interaction
10364424 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
10364424 MGI
involved in somitogenesis IGI
IGI: Inferred from genetic interaction
11562355 MGI
acts upstream of or within ureteric bud development IMP
IMP: Inferred from mutant phenotype
10704385 MGI
acts upstream of or within vascular endothelial growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
16678147 MGI
acts upstream of or within ventricular cardiac muscle tissue morphogenesis IGI
IGI: Inferred from genetic interaction
16839542 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

forkhead box protein C2

  • BF-3

  • brain factor 3

  • forkhead homolog 14

  • forkhead-related protein FKHL14

  • mesenchyme fork head protein 1

  • transcription factor FKH-14

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149894 MC-1-F2 Inhibitor 99.69% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxc2 NCBI NCBI:2303